CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023278
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 5-azacytidine-induced protein 1 
Protein Synonyms/Alias
 Centrosomal protein of 131 kDa; Cep131; Pre-acrosome localization protein 1 
Gene Name
 AZI1 
Gene Synonyms/Alias
 CEP131; KIAA1118 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
40PGSAATTKPIVRSVSubiquitination[1]
110EGSPSGKKRPASLSTubiquitination[1, 2]
122LSTAPSEKGATWNVLubiquitination[1]
157SPAGPRRKECTVALAubiquitination[2]
175TANNRSNKGAVGNCVubiquitination[2]
200SERAPPLKSSNQTAPubiquitination[1, 2]
214PSLNNIIKAATCEGSubiquitination[2]
228SESSGFGKLPKNVSSubiquitination[2]
231SGFGKLPKNVSSATHubiquitination[2]
254STGLPRRKEVTEEEAubiquitination[1]
300LEHLLQAKREEQRQRubiquitination[2]
320LLDLHQQKEAARRKAubiquitination[1, 2]
346AIQELQQKRALRAQKubiquitination[1, 2]
353KRALRAQKASTAERGubiquitination[2]
504LTADNLEKFGKLSAFubiquitination[2, 3, 4]
507DNLEKFGKLSAFPEPubiquitination[1, 2]
574STSVMRLKLEVEEKKubiquitination[2]
639DQLIEDKKVLSEKCEubiquitination[2]
644DKKVLSEKCEAVVAEubiquitination[2]
653EAVVAELKQEDQRCTubiquitination[2]
675AQHELEIKKLKELMSubiquitination[1]
676QHELEIKKLKELMSAubiquitination[2]
678ELEIKKLKELMSATEubiquitination[2]
686ELMSATEKARREKWIubiquitination[2]
701SEKTKKIKEVTVRGLubiquitination[2]
714GLEPEIQKLIARHKQubiquitination[2]
873WEAGRTRKEEAWLLNubiquitination[2]
952QERCSELKGQLGEAEubiquitination[2]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 May play a role in spermatogenesis (By similarity). 
Sequence Annotation
 DOMAIN 269 289 IQ.
 MOD_RES 47 47 Phosphoserine.
 MOD_RES 78 78 Phosphoserine.
 MOD_RES 79 79 Phosphothreonine (By similarity).
 MOD_RES 89 89 Phosphoserine.
 MOD_RES 105 105 Phosphoserine.
 MOD_RES 150 150 Phosphoserine.
 MOD_RES 453 453 Phosphoserine.
 MOD_RES 798 798 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Phosphoprotein; Polymorphism; Reference proteome; Spermatogenesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1083 AA 
Protein Sequence
MKGTRAIGSV PERSPAGVDL SLTGLPPPVS RRPGSAATTK PIVRSVSVVT GSEQKRKVLE 60
ATGPGGSQAI NNLRRSNSTT QVSQPRSGSP RPTEPTDFLM LFEGSPSGKK RPASLSTAPS 120
EKGATWNVLD DQPRGFTLPS NARSSSALDS PAGPRRKECT VALAPNFTAN NRSNKGAVGN 180
CVTTMVHNRY TPSERAPPLK SSNQTAPSLN NIIKAATCEG SESSGFGKLP KNVSSATHSA 240
RNNTGGSTGL PRRKEVTEEE AERFIHQVNQ ATVTIQRWYR HQVQRRGAGA ARLEHLLQAK 300
REEQRQRSGE GTLLDLHQQK EAARRKAREE KARQARRAAI QELQQKRALR AQKASTAERG 360
PPENPRETRV PGMRQPAQEL SPTPGGTAHQ ALKANNTGGG LPAAGPGDRC LPTSDSSPEP 420
QQPPEDRTQD VLAQDAAGDN LEMMAPSRGS AKSRGPLEEL LHTLQLLEKE PDVLPRPRTH 480
HRGRYAWASE EDDASSLTAD NLEKFGKLSA FPEPPEDGTL LSEAKLQSIM SFLDEMEKSG 540
QDQLDSQQEG WVPEAGPGPL ELGSEVSTSV MRLKLEVEEK KQAMLLLQRA LAQQRDLTAR 600
RVKETEKALS RQLQRQREHY EATIQRHLAF IDQLIEDKKV LSEKCEAVVA ELKQEDQRCT 660
ERVAQAQAQH ELEIKKLKEL MSATEKARRE KWISEKTKKI KEVTVRGLEP EIQKLIARHK 720
QEVRRLKSLH EAELLQSDER ASQRCLRQAE ELREQLEREK EALGQQERER ARQRFQQHLE 780
QEQWALQQQR QRLYSEVAEE RERLGQQAAR QRAELEELRQ QLEESSSALT RALRAEFEKG 840
REEQERRHQM ELNTLKQQLE LERQAWEAGR TRKEEAWLLN REQELREEIR KGRDKEIELV 900
IHRLEADMAL AKEESEKAAE SRIKRLRDKY EAELSELEQS ERKLQERCSE LKGQLGEAEG 960
ENLRLQGLVR QKERALEDAQ AVNEQLSSER SNLAQVIRQE FEDRLAASEE ETRQAKAELA 1020
TLQARQQLEL EEVHRRVKTA LARKEEAVSS LRTQHEAAVK RADHLEELLE QHRRPTPSTK 1080 
Gene Ontology
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW. 
Interpro
  
Pfam
  
SMART
  
PROSITE
 PS50096; IQ 
PRINTS