| Tag | Content |
|---|
| CPLM ID | CPLM-002309 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Hsp90 co-chaperone Cdc37 |
Protein Synonyms/Alias | Cell division control protein 37; Hsp90 chaperone protein kinase-targeting subunit |
Gene Name | CDC37 |
Gene Synonyms/Alias | SMO1; YDR168W; YD9489.03 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 348 | FLRSVQEKFLHIQKR | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Involved in both the HOG and the PKC MAP kinase signaling cascade necessary for adaptation to stress conditions due to high osmolarity or cell wall perturbation. |
Sequence Annotation | MOD_RES 14 14 Phosphoserine.
MOD_RES 17 17 Phosphoserine.
MOD_RES 367 367 Phosphoserine.
MOD_RES 466 466 Phosphoserine.
MOD_RES 484 484 Phosphoserine. |
Keyword | Cell cycle; Cell division; Chaperone; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 506 AA |
Protein Sequence | MAIDYSKWDK IELSDDSDVE VHPNVDKKSF IKWKQQSIHE QRFKRNQDIK NLETQVDMYS 60
HLNKRVDRIL SNLPESSLTD LPAVTKFLNA NFDKMEKSKG ENVDPEIATY NEMVEDLFEQ 120
LAKDLDKEGK DSKSPSLIRD AILKHRAKID SVTVEAKKKL DELYKEKNAH ISSEDIHTGF 180
DSSFMNKQKG GAKPLEATPS EALSSAAESN ILNKLAKSSV PQTFIDFKDD PMKLAKETEE 240
FGKISINEYS KSQKFLLEHL PIISEQQKDA LMMKAFEYQL HGDDKMTLQV IHQSELMAYI 300
KEIYDMKKIP YLNPMELSNV INMFFEKVIF NKDKPMGKES FLRSVQEKFL HIQKRSKILQ 360
QEEMDESNAE GVETIQLKSL DDSTELEVNL PDFNSKDPEE MKKVKVFKTL IPEKMQEAIM 420
TKNLDNINKV FEDIPIEEAE KLLEVFNDID IIGIKAILEN EKDFQSLKDQ YEQDHEDATM 480
ENLSLNDRDG GGDNHEEVKH TADTVD 506 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:SGD. GO:0051082; F:unfolded protein binding; IDA:SGD. GO:0051301; P:cell division; IEA:UniProtKB-KW. GO:0000161; P:MAPK cascade involved in osmosensory signaling pathway; IMP:SGD. GO:0050821; P:protein stabilization; IMP:SGD. GO:0051726; P:regulation of cell cycle; IMP:SGD. GO:0032872; P:regulation of stress-activated MAPK cascade; IMP:SGD. GO:0007103; P:spindle pole body duplication associated with nuclear envelope; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |