UniProt Accession

 SEPT8_HUMAN; Q92599; A6NC65; A6NKP6; Q8IX36; Q8IX37; Q9BVB3 

Genbank Protein ID

 D86957; AF179995; AF440761; AF440762; AF440763; AC004775; CH471062; CH471062; BC001329 

Genbank Nucleotide ID

 BAA13193.1; AAG09407.1; AAO13878.1; AAO13879.1; AAO13880.1; EAW62315.1; EAW62317.1; AAH01329.1 

Protein Name

 Septin-8 

Protein Synonyms/Alias

  

Gene Name

 SEPT8 

Gene Synonyms/Alias

 KIAA0202 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
173	SLDLVTMKKLDSKVN	ubiquitination	[1]
178	TMKKLDSKVNIIPII	ubiquitination	[1]
193	AKADTISKSELHKFK	ubiquitination	[1]
202	ELHKFKIKIMGELVS	ubiquitination	[1]
304	YELYRRCKLEEMGFQ	ubiquitination	[1]
331	ETYEAKRKEFLSELQ	ubiquitination	[1, 2]
353	QMFVNKVKETELELK	ubiquitination	[1]
360	KETELELKEKERELH	ubiquitination	[1]
369	KERELHEKFEHLKRV	ubiquitination	[1]
387	EKRKVEEKRRELEEE	acetylation	[3]
402	TNAFNRRKAAVEALQ	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. 

Sequence Annotation

 NP_BIND 51 58 GTP (By similarity).
 NP_BIND 187 195 GTP (By similarity).
 BINDING 106 106 GTP; via amide nitrogen (By similarity).
 BINDING 241 241 GTP; via amide nitrogen and carbonyl
 BINDING 256 256 GTP (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 10 10 Phosphoserine (By similarity).
 MOD_RES 141 141 Phosphoserine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; GTP-binding; Nucleotide-binding; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 483 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0031105; C:septin complex; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0007049; P:cell cycle; IEA:InterPro. 

Interpro

 IPR000038; Cell_div_GTP-bd.
 IPR027417; P-loop_NTPase.
 IPR016491; Septin. 

Pfam

 PF00735; Septin 

SMART

  

PROSITE

  

PRINTS