CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000287
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Programmed cell death protein 5 
Protein Synonyms/Alias
 TF-1 cell apoptosis-related protein 19; Protein TFAR19 
Gene Name
 PDCD5 
Gene Synonyms/Alias
 TFAR19 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
20RLAELQAKHGDPGDAubiquitination[1, 2, 3, 4]
33DAAQQEAKHREAEMRubiquitination[1, 3, 4]
63LSNLALVKPEKTKAVacetylation[5]
63LSNLALVKPEKTKAVubiquitination[1, 4]
68LVKPEKTKAVENYLIubiquitination[1, 4, 6]
97QGLIEILKKVSQQTEubiquitination[1, 2, 4]
98GLIEILKKVSQQTEKubiquitination[3]
105KVSQQTEKTTTVKFNubiquitination[3]
110TEKTTTVKFNRRKVMubiquitination[1, 4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [6] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965
Functional Description
 May function in the process of apoptosis. 
Sequence Annotation
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 63 63 N6-acetyllysine.
 MOD_RES 119 119 Phosphoserine.  
Keyword
 3D-structure; Acetylation; Apoptosis; Complete proteome; Direct protein sequencing; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 125 AA 
Protein Sequence
MADEELEALR RQRLAELQAK HGDPGDAAQQ EAKHREAEMR NSILAQVLDQ SARARLSNLA 60
LVKPEKTKAV ENYLIQMARY GQLSEKVSEQ GLIEILKKVS QQTEKTTTVK FNRRKVMDSD 120
EDDDY 125 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0043065; P:positive regulation of apoptotic process; IMP:FlyBase. 
Interpro
 IPR002836; TFAR19_DNA-bd. 
Pfam
 PF01984; dsDNA_bind 
SMART
  
PROSITE
  
PRINTS