CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018313
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Secreted and transmembrane protein 1 
Protein Synonyms/Alias
 Protein K-12 
Gene Name
 SECTM1 
Gene Synonyms/Alias
 K12 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
181SQQRREKKFFLLEPQubiquitination[1, 2]
190FLLEPQMKVAALRAGubiquitination[3, 4, 5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 May be involved in thymocyte signaling. 
Sequence Annotation
 CARBOHYD 56 56 N-linked (GlcNAc...) (Potential).
 DISULFID 38 55 Potential.  
Keyword
 Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Reference proteome; Secreted; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 248 AA 
Protein Sequence
MQTCPLAFPG HVSQALGTLL FLAASLSAQN EGWDSPICTE GVVSVSWGEN TVMSCNISNA 60
FSHVNIKLRA HGQESAIFNE VAPGYFSRDG WQLQVQGGVA QLVIKGARDS HAGLYMWHLV 120
GHQRNNRQVT LEVSGAEPQS APDTGFWPVP AVVTAVFILL VALVMFAWYR CRCSQQRREK 180
KFFLLEPQMK VAALRAGAQQ GLSRASAELW TPDSEPTPRP LALVFKPSPL GALELLSPQP 240
LFPYAADP 248 
Gene Ontology
 GO:0005615; C:extracellular space; TAS:ProtInc.
 GO:0005794; C:Golgi apparatus; TAS:ProtInc.
 GO:0016021; C:integral to membrane; TAS:ProtInc.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005125; F:cytokine activity; TAS:ProtInc.
 GO:0004871; F:signal transducer activity; IMP:UniProtKB.
 GO:0006955; P:immune response; TAS:ProtInc.
 GO:0007498; P:mesoderm development; TAS:ProtInc.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS