| Tag | Content |
|---|
| CPLM ID | CPLM-022940 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Zinc finger transcription factor Trps1 |
Protein Synonyms/Alias | Tricho-rhino-phalangeal syndrome type I protein; Zinc finger protein GC79 |
Gene Name | TRPS1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1192 | TKAPPNVKNEGPLNV | sumoylation | [1] | | 1201 | EGPLNVVKTEKVDRS | sumoylation | [1] |
|
Reference | [1] SUMOylation modulates transcriptional repression by TRPS1. Kaiser FJ, Lüdecke HJ, Weger S. Biol Chem. 2007 Apr;388(4):381-90. [ PMID: 17391059] |
Functional Description | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. |
Sequence Annotation | ZN_FING 222 247 C2H2-type 1; atypical.
ZN_FING 333 358 C2H2-type 2; atypical.
ZN_FING 614 637 C2H2-type 3; atypical.
ZN_FING 666 689 C2H2-type 4.
ZN_FING 692 715 C2H2-type 5.
ZN_FING 896 920 GATA-type.
ZN_FING 1215 1237 C2H2-type 6.
ZN_FING 1243 1267 C2H2-type 7.
REGION 635 819 Mediates interaction with GLI3.
REGION 985 1184 Mediates interaction with RNF4 (By
REGION 1163 1281 Transcriptional repressor domain (By
MOD_RES 751 751 Phosphothreonine.
MOD_RES 1041 1041 Phosphoserine.
MOD_RES 1085 1085 Phosphoserine.
CROSSLNK 1192 1192 Glycyl lysine isopeptide (Lys-Gly)
CROSSLNK 1201 1201 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Alternative splicing; Complete proteome; Disease mutation; DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1281 AA |
Protein Sequence | MVRKKNPPLR NVASEGEGQI LEPIGTESKV SGKNKEFSAD QMSENTDQSD AAELNHKEEH 60
SLHVQDPSSS SKKDLKSAVL SEKAGFNYES PSKGGNFPSF PHDEVTDRNM LAFSSPAAGG 120
VCEPLKSPQR AEADDPQDMA CTPSGDSLET KEDQKMSPKA TEETGQAQSG QANCQGLSPV 180
SVASKNPQVP SDGGVRLNKS KTDLLVNDNP DPAPLSPELQ DFKCNICGYG YYGNDPTDLI 240
KHFRKYHLGL HNRTRQDAEL DSKILALHNM VQFSHSKDFQ KVNRSVFSGV LQDINSSRPV 300
LLNGTYDVQV TSGGTFIGIG RKTPDCQGNT KYFRCKFCNF TYMGNSSTEL EQHFLQTHPN 360
KIKASLPSSE VAKPSEKNSN KSIPALQSSD SGDLGKWQDK ITVKAGDDTP VGYSVPIKPL 420
DSSRQNGTEA TSYYWCKFCS FSCESSSSLK LLEHYGKQHG AVQSGGLNPE LNDKLSRGSV 480
INQNDLAKSS EGETMTKTDK SSSGAKKKDF SSKGAEDNMV TSYNCQFCDF RYSKSHGPDV 540
IVVGPLLRHY QQLHNIHKCT IKHCPFCPRG LCSPEKHLGE ITYPFACRKS NCSHCALLLL 600
HLSPGAAGSS RVKHQCHQCS FTTPDVDVLL FHYESVHESQ ASDVKQEANH LQGSDGQQSV 660
KESKEHSCTK CDFITQVEEE ISRHYRRAHS CYKCRQCSFT AADTQSLLEH FNTVHCQEQD 720
ITTANGEEDG HAISTIKEEP KIDFRVYNLL TPDSKMGEPV SESVVKREKL EEKDGLKEKV 780
WTESSSDDLR NVTWRGADIL RGSPSYTQAS LGLLTPVSGT QEQTKTLRDS PNVEAAHLAR 840
PIYGLAVETK GFLQGAPAGG EKSGALPQQY PASGENKSKD ESQSLLRRRR GSGVFCANCL 900
TTKTSLWRKN ANGGYVCNAC GLYQKLHSTP RPLNIIKQNN GEQIIRRRTR KRLNPEALQA 960
EQLNKQQRGS NEEQVNGSPL ERRSEDHLTE SHQREIPLPS LSKYEAQGSL TKSHSAQQPV 1020
LVSQTLDIHK RMQPLHIQIK SPQESTGDPG NSSSVSEGKG SSERGSPIEK YMRPAKHPNY 1080
SPPGSPIEKY QYPLFGLPFV HNDFQSEADW LRFWSKYKLS VPGNPHYLSH VPGLPNPCQN 1140
YVPYPTFNLP PHFSAVGSDN DIPLDLAIKH SRPGPTANGA SKEKTKAPPN VKNEGPLNVV 1200
KTEKVDRSTQ DELSTKCVHC GIVFLDEVMY ALHMSCHGDS GPFQCSICQH LCTDKYDFTT 1260
HIQRGLHRNN AQVEKNGKPK E 1281 |
Gene Ontology | GO:0005634; C:nucleus; IDA:UniProtKB. GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc. GO:0008270; F:zinc ion binding; TAS:ProtInc. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB. GO:0006607; P:NLS-bearing substrate import into nucleus; TAS:ProtInc. GO:0032330; P:regulation of chondrocyte differentiation; ISS:UniProtKB. GO:0001501; P:skeletal system development; TAS:ProtInc. GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |