UniProt Accession

 RAB1A_MOUSE; P62821; P11476; Q3TX44; Q811M4; Q96N61; Q9Y3T2 

Genbank Protein ID

 Y00094; X15744; X15745; X15746; X15747; AF226873; AK034408; AK159425; AK166249; AK167150; BC002077 

Genbank Nucleotide ID

 CAA68284.1; CAA33760.1; CAA33760.1; CAA33760.1; CAA33760.1; AAF33844.1; BAC28697.1; BAE35072.1; BAE38660.1; BAE39292.1; AAH02077.3 

Protein Name

 Ras-related protein Rab-1A 

Protein Synonyms/Alias

 YPT1-related protein 

Gene Name

 Rab1A 

Gene Synonyms/Alias

 Rab1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
24	IGDSGVGKSCLLLRF	acetylation	[1]
58	RTIELDGKTIKLQIW	acetylation	[2]
58	RTIELDGKTIKLQIW	ubiquitination	[3]
61	ELDGKTIKLQIWDTA	acetylation	[2, 4]
61	ELDGKTIKLQIWDTA	ubiquitination	[3]
119	YASENVNKLLVGNKC	acetylation	[1]
119	YASENVNKLLVGNKC	ubiquitination	[3]
125	NKLLVGNKCDLTTKK	ubiquitination	[3]
131	NKCDLTTKKVVDYTT	ubiquitination	[3]
187	ATAGGAEKSNVKIQS	acetylation	[4]
187	ATAGGAEKSNVKIQS	succinylation	[4]
187	ATAGGAEKSNVKIQS	ubiquitination	[3]
191	GAEKSNVKIQSTPVK	ubiquitination	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity. 

Sequence Annotation

 NP_BIND 18 26 GTP (By similarity).
 NP_BIND 66 70 GTP (By similarity).
 NP_BIND 124 127 GTP (By similarity).
 NP_BIND 154 156 GTP (By similarity).
 MOTIF 40 48 Effector region (By similarity).
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 79 79 O-(2-cholinephosphoryl)serine (By
 MOD_RES 194 194 Phosphoserine; by CDK1 (By similarity).
 LIPID 204 204 S-geranylgeranyl cysteine (By
 LIPID 205 205 S-geranylgeranyl cysteine (By  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; GTP-binding; Lipoprotein; Nucleotide-binding; Phosphoprotein; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 205 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; ISA:MGI.
 GO:0006886; P:intracellular protein transport; TAS:MGI.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.