CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039474
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Transformation/transcription domain-associated protein 
Protein Synonyms/Alias
  
Gene Name
 TRRAP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
84EVQFLQEKPAQQLRKubiquitination[1]
470QLSAIFKKCKPQSELubiquitination[2]
551TDCRSLVKTLVCGVKubiquitination[2]
896VAYRVLGKFGGSNRKubiquitination[2, 3, 4]
940SLQLPMEKAIETALDubiquitination[2]
950ETALDCLKSANTEPYubiquitination[2, 4]
1015AQDTPARKTFEQALTubiquitination[2]
1221MRCATPLKDEERAEEubiquitination[4]
1356LTKLPCYKSLPSLVPubiquitination[2, 4]
1384YLPQSREKIIAALFKubiquitination[2]
1672NMAATNWKEPKLLAYmethylation[5]
1750PNFGDELKAKVLQHIubiquitination[1, 2, 6]
1752FGDELKAKVLQHILNubiquitination[2]
1795ITSVFITKVLDPEKQubiquitination[6]
2003KWELQRIKDQQPDSDubiquitination[1, 2, 6]
2028NSVSSSIKRGLSVDSubiquitination[1, 6]
2040VDSAQEVKRFRTATGubiquitination[2, 4]
2068GADSLLAKPIDKQHTubiquitination[2]
2072LLAKPIDKQHTDTVVubiquitination[2]
2188CMTCGNTKVLRAVHSubiquitination[2]
2387KMMTYIEKRFPEDLEmethylation[5]
2420SGSELTAKLEPAFLSubiquitination[1]
2439AQPLIRAKFFEVFDNubiquitination[2]
2525FAMVTHVKQEPREREacetylation[4]
2525FAMVTHVKQEPREREubiquitination[2]
2579MLTNRHDKFLDTLREubiquitination[3]
2620QLFPRLWKILSDRQQubiquitination[3]
2706KGLSLQIKPKQTTEFubiquitination[2]
2811DHWIRCSKELNQWEAubiquitination[2]
2950NNSLHDMKTVVKTWRubiquitination[2, 4]
2954HDMKTVVKTWRNRLPubiquitination[2, 3]
3021QYGKIARKQGLVNVAubiquitination[1, 2, 3, 4]
3049PIVDCFQKIRQQVKCubiquitination[2, 4]
3256IEQRERYKSDSGQQQubiquitination[1]
3335QLQQGLAKCYSVAFEubiquitination[2]
3343CYSVAFEKSGAVSDAubiquitination[2, 4]
3351SGAVSDAKITPHTLNubiquitination[2, 4]
3361PHTLNFVKKLVSTFGubiquitination[1]
3362HTLNFVKKLVSTFGVubiquitination[2]
3404AQDPVFQKLKGQFTTubiquitination[1]
3406DPVFQKLKGQFTTDFubiquitination[2]
3453KFFLIEEKCRFLSNFubiquitination[2]
3497PRVEIVQKHNTAARRubiquitination[2, 4]
3547LLNPCLEKRKETTKRubiquitination[2]
3587LSLVEIYKQRCAKKGubiquitination[1, 2, 4, 6]
3593YKQRCAKKGIEHDNPubiquitination[2]
3628QVLRDILKEVQSNMVubiquitination[1, 2, 4]
3754CFAQPNFKVDGILKTubiquitination[2]
3823QFEGGESKVNTLVAAubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3848 AA 
Protein Sequence
MAFVATQGAT VVDQTTLMKK YLQFVAALTD VNTPDETKLK MMQEVSENFE NVTSSPQYST 60
FLEHIIPRFL TFLQDGEVQF LQEKPAQQLR KLVLEIIHRI PTNEHLRPHT KNVLSVMFRF 120
LETENEENVL ICLRIIIELH KQFRPPITQE IHHFLDFVKQ IYKELPKVVN RYFENPQVIP 180
ENTVPPPEMV GMITTIAVKV NPEREDSETR THSIIPRGSL SLKVLAELPI IVVLMYQLYK 240
LNIHNVVAEF VPLIMNTIAI QVSAQARQHK LYNKELYADF IAAQIKTLSF LAYIIRIYQE 300
LVTKYSQQMV KGMLQLLSNC PAETAHLRKE LLIAAKHILT TELRNQFIPC MDKLFDESIL 360
IGSGYTARET LRPLAYSTLA DLVHHVRQHL PLSDLSLAVQ LFAKNIDDES LPSSIQTMSC 420
KLLLNLVDCI RSKSEQESGN GRDVLMRMLE VFVLKFHTIA RYQLSAIFKK CKPQSELGAV 480
EAALPGVPTA PAAPGPAPSP APVPAPPPPP PPPPPATPVT PAPVPPFEKQ GEKDKEDKQT 540
FQVTDCRSLV KTLVCGVKTI TWGITSCKAP GAQFIPNKQL QPKETQIYIK LVKYAMQALD 600
IYQVQIAGNG QTYIRVANCQ TVRMKEEKEV LEHFAGVFTM MNPLTFKEIF QTTVPYMVER 660
ISKNYALQIV ANSFLANPTT SALFATILVE YLLDRLPEMG SNVELSNLYL KLFKLVFGSV 720
SLFAAENEQM LKPHLHKIVN SSMELAQTAK EPYNYFLLLR ALFRSIGGGS HDLLYQEFLP 780
LLPNLLQGLN MLQSGLHKQH MKDLFVELCL TVPVRLSSLL PYLPMLMDPL VSALNGSQTL 840
VSQGLRTLEL CVDNLQPDFL YDHIQPVRAE LMQALWRTLR NPADSISHVA YRVLGKFGGS 900
NRKMLKESQK LHYVVTEVQG PSITVEFSDC KASLQLPMEK AIETALDCLK SANTEPYYRR 960
QAWEVIKCFL VAMMSLEDNK HALYQLLAHP NFTEKTIPNV IISHRYKAQD TPARKTFEQA 1020
LTGAFMSAVI KDLRPSALPF VASLIRHYTM VAVAQQCGPF LLPCYQVGSQ PSTAMFHSEE 1080
NGSKGMDPLV LIDAIAICMA YEEKELCKIG EVALAVIFDV ASIILGSKER ACQLPLFSYI 1140
VERLCACCYE QAWYAKLGGV VSIKFLMERL PLTWVLQNQQ TFLKALLFVM MDLTGEVSNG 1200
AVAMAKTTLE QLLMRCATPL KDEERAEEIV AAQEKSFHHV THDLVREVTS PNSTVRKQAM 1260
HSLQVLAQVT GKSVTVIMEP HKEVLQDMVP PKKHLLRHQP ANAQIGLMEG NTFCTTLQPR 1320
LFTMDLNVVE HKVFYTELLN LCEAEDSALT KLPCYKSLPS LVPLRIAALN ALAACNYLPQ 1380
SREKIIAALF KALNSTNSEL QEAGEACMRK FLEGATIEVD QIHTHMRPLL MMLGDYRSLT 1440
LNVVNRLTSV TRLFPNSFND KFCDQMMQHL RKWMEVVVIT HKGGQRSDGN EMKICSAIIN 1500
LFHLIPAAPQ TLVKPLLEVV MKTERAMLIE AGSPFREPLI KFLTRHPSQT VELFMMEATL 1560
NDPQWSRMFM SFLKHKDARP LRDVLAANPN RFITLLLPGG AQTAVRPGSP STSTMRLDLQ 1620
FQAIKIISII VKNDDSWLAS QHSLVSQLRR VWVSENFQER HRKENMAATN WKEPKLLAYC 1680
LLNYCKRNYG DIELLFQLLR AFTGRFLCNM TFLKEYMEEE IPKNYSIAQK RALFFRFVDF 1740
NDPNFGDELK AKVLQHILNP AFLYSFEKGE GEQLLGPPNP EGDNPESITS VFITKVLDPE 1800
KQADMLDSLR IYLLQYATLL VEHAPHHIHD NNKNRNSKLR RLMTFAWPCL LSKACVDPAC 1860
KYSGHLLLAH IIAKFAIHKK IVLQVFHSLL KAHAMEARAI VRQAMAILTP AVPARMEDGH 1920
QMLTHWTRKI IVEEGHTVPQ LVHILHLIVQ HFKVYYPVRH HLVQHMVSAM QRLGFTPSVT 1980
IEQRRLAVDL SEVVIKWELQ RIKDQQPDSD MDPNSSGEGV NSVSSSIKRG LSVDSAQEVK 2040
RFRTATGAIS AVFGRSQSLP GADSLLAKPI DKQHTDTVVN FLIRVACQVN DNTNTAGSPG 2100
EVLSRRCVNL LKTALRPDMW PKSELKLQWF DKLLMTVEQP NQVNYGNICT GLEVLSFLLT 2160
VLQSPAILSS FKPLQRGIAA CMTCGNTKVL RAVHSLLSRL MSIFPTEPST SSVASKYEEL 2220
ECLYAAVGKV IYEGLTNYEK ATNANPSQLF GTLMILKSAC SNNPSYIDRL ISVFMRSLQK 2280
MVREHLNPQA ASGSTEATSA GTSELVMLSL ELVKTRLAVM SMEMRKNFIQ AILTSLIEKS 2340
PDAKILRAVV KIVEEWVKNN SPMAANQTPT LREKSILLVK MMTYIEKRFP EDLELNAQFL 2400
DLVNYVYRDE TLSGSELTAK LEPAFLSGLR CAQPLIRAKF FEVFDNSMKR RVYERLLYVT 2460
CSQNWEAMGN HFWIKQCIEL LLAVCEKSTP IGTSCQGAML PSITNVINLA DSHDRAAFAM 2520
VTHVKQEPRE RENSESKEED VEIDIELAPG DQTSTPKTKE LSEKDIGNQL HMLTNRHDKF 2580
LDTLREVKTG ALLSAFVQLC HISTTLAEKT WVQLFPRLWK ILSDRQQHAL AGEISPFLCS 2640
GSHQVQRDCQ PSALNCFVEA MSQCVPPIPI RPCVLKYLGK THNLWFRSTL MLEHQAFEKG 2700
LSLQIKPKQT TEFYEQESIT PPQQEILDSL AELYSLLQEE DMWAGLWQKR CKYSETATAI 2760
AYEQHGFFEQ AQESYEKAMD KAKKEHERSN ASPAIFPEYQ LWEDHWIRCS KELNQWEALT 2820
EYGQSKGHIN PYLVLECAWR VSNWTAMKEA LVQVEVSCPK EMAWKVNMYR GYLAICHPEE 2880
QQLSFIERLV EMASSLAIRE WRRLPHVVSH VHTPLLQAAQ QIIELQEAAQ INAGLQPTNL 2940
GRNNSLHDMK TVVKTWRNRL PIVSDDLSHW SSIFMWRQHH YQAIVTAYEN SSQHDPSSNN 3000
AMLGVHASAS AIIQYGKIAR KQGLVNVALD ILSRIHTIPT VPIVDCFQKI RQQVKCYLQL 3060
AGVMGKNECM QGLEVIESTN LKYFTKEMTA EFYALKGMFL AQINKSEEAN KAFSAAVQMH 3120
DVLVKAWAMW GDYLENIFVK ERQLHLGVSA ITCYLHACRH QNESKSRKYL AKVLWLLSFD 3180
DDKNTLADAV DKYCIGVPPI QWLAWIPQLL TCLVGSEGKL LLNLISQVGR VYPQAVYFPI 3240
RTLYLTLKIE QRERYKSDSG QQQPSSVGNQ SHSASDPGPI RATAPMWRCS RIMHMQRELH 3300
PTLLSSLEGI VDQMVWFREN WHEEVLRQLQ QGLAKCYSVA FEKSGAVSDA KITPHTLNFV 3360
KKLVSTFGVG LENVSNVSTM FSSAASESLA RRAQATAQDP VFQKLKGQFT TDFDFSVPGS 3420
MKLHNLISKL KKWIKILEAK TKQLPKFFLI EEKCRFLSNF SAQTAEVEIP GEFLMPKPTH 3480
YYIKIARFMP RVEIVQKHNT AARRLYIRGH NGKIYPYLVM NDACLTESRR EERVLQLLRL 3540
LNPCLEKRKE TTKRHLFFTV PRVVAVSPQM RLVEDNPSSL SLVEIYKQRC AKKGIEHDNP 3600
ISRYYDRLAT VQARGTQASH QVLRDILKEV QSNMVPRSML KEWALHTFPN ATDYWTFRKM 3660
FTIQLALIGF AEFVLHLNRL NPEMLQIAQD TGKLNVAYFR FDINDATGDL DANRPVPFRL 3720
TPNISEFLTT IGVSGPLTAS MIAVARCFAQ PNFKVDGILK TVLRDEIIAW HKKTQEDTSS 3780
PLSAAGQPEN MDSQQLVSLV QKAVTAIMTR LHNLAQFEGG ESKVNTLVAA ANSLDNLCRM 3840
DPAWHPWL 3848 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR003152; FATC.
 IPR011009; Kinase-like_dom.
 IPR000403; PI3/4_kinase_cat_dom.
 IPR003151; PIK-rel_kinase_FAT.
 IPR014009; PIK_FAT.
 IPR011990; TPR-like_helical. 
Pfam
 PF02259; FAT
 PF00454; PI3_PI4_kinase 
SMART
 SM00146; PI3Kc 
PROSITE
 PS51189; FAT
 PS51190; FATC
 PS50290; PI3_4_KINASE_3 
PRINTS