UniProt Accession

 KLH15_HUMAN; Q96M94; Q32MN3; Q8NDA3; Q96BM6; Q9C0I6 

Genbank Protein ID

 AK057298; BC015415; BC109058; BC109059; AB051464; AL834313 

Genbank Nucleotide ID

 BAB71415.1; AAH15415.1; AAI09059.1; AAI09060.1; BAB21768.1; CAD38983.1 

Protein Name

 Kelch-like protein 15 

Protein Synonyms/Alias

  

Gene Name

 KLHL15 

Gene Synonyms/Alias

 KIAA1677 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
237	TSVFEKVKTSEFYRY	ubiquitination	[1]
271	QQPLLDMKSSRIRSA	ubiquitination	[1, 2, 3]
279	SSRIRSAKPQTTVFR	ubiquitination	[1]
405	RYDITNDKWEFVDPY	ubiquitination	[1, 2]
471	VTNCWENKSKMNYAR	ubiquitination	[1]
473	NCWENKSKMNYARCF	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 

Sequence Annotation

 DOMAIN 31 98 BTB.
 DOMAIN 133 237 BACK.
 REPEAT 328 379 Kelch 1.
 REPEAT 381 426 Kelch 2.
 REPEAT 428 473 Kelch 3.
 REPEAT 489 542 Kelch 4.
 REPEAT 544 590 Kelch 5.  

Keyword

 Complete proteome; Kelch repeat; Reference proteome; Repeat; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 604 AA 

Protein Sequence

Gene Ontology

 GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. 

Interpro

 IPR011705; BACK.
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR017096; Kelch-like_gigaxonin.
 IPR015915; Kelch-typ_b-propeller.
 IPR006652; Kelch_1. 

Pfam

 PF07707; BACK
 PF00651; BTB
 PF01344; Kelch_1 

SMART

 SM00875; BACK
 SM00225; BTB
 SM00612; Kelch 

PROSITE

 PS50097; BTB 

PRINTS