UniProt Accession

 CAMLG_HUMAN; P49069; A1L3Y3 

Genbank Protein ID

 U18242; AK313156; CH471062; CH471062; BC130325; AF068179 

Genbank Nucleotide ID

 AAA59420.1; BAG35974.1; EAW62243.1; EAW62244.1; AAI30326.1; AAC23596.1 

Protein Name

 Calcium signal-modulating cyclophilin ligand 

Protein Synonyms/Alias

 CAML 

Gene Name

 CAMLG 

Gene Synonyms/Alias

 CAML 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
72	SKQQDSDKLNSLSVP	acetylation	[1]
83	LSVPSVSKRVVLGDS	acetylation	[1]
164	SRFEEAMKLRKQLIS	ubiquitination	[2, 3]
173	RKQLISEKPSQEDGN	ubiquitination	[2]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. 

Sequence Annotation

  

Keyword

 Complete proteome; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 296 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0006952; P:defense response; TAS:ProtInc.
 GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:Compara.
 GO:0001881; P:receptor recycling; IEA:Compara.
 GO:0007165; P:signal transduction; TAS:ProtInc. 

Interpro

 IPR016719; Ca_signal-mod_cyclophilin_lig. 

Pfam

  

SMART

  

PROSITE

  

PRINTS