UniProt Accession

 G3V4I6_HUMAN; G3V4I6 

Genbank Protein ID

 AL583722; AL590327 

Genbank Nucleotide ID

  

Protein Name

 RAC-alpha serine/threonine-protein kinase 

Protein Synonyms/Alias

  

Gene Name

 AKT1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
8	MSDVAIVKEGWLHKR	ubiquitination	[1, 2, 3]
30	RPRYFLLKNDGTFIG	ubiquitination	[1, 2]
39	DGTFIGYKERPQDVD	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 92 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0030027; C:lamellipodium; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005819; C:spindle; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:Compara.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0004672; F:protein kinase activity; IEA:Compara.
 GO:0007568; P:aging; IEA:Compara.
 GO:0042640; P:anagen; IEA:Compara.
 GO:0008637; P:apoptotic mitochondrial changes; IEA:Compara.
 GO:0030030; P:cell projection organization; IEA:Compara.
 GO:0071364; P:cellular response to epidermal growth factor stimulus; IEA:Compara.
 GO:0071456; P:cellular response to hypoxia; IEA:Compara.
 GO:0032869; P:cellular response to insulin stimulus; IEA:Compara.
 GO:0007281; P:germ cell development; IEA:Compara.
 GO:0042593; P:glucose homeostasis; IEA:Compara.
 GO:0006006; P:glucose metabolic process; IEA:Compara.
 GO:0015758; P:glucose transport; IEA:Compara.
 GO:0005978; P:glycogen biosynthetic process; IEA:Compara.
 GO:0060709; P:glycogen cell differentiation involved in embryonic placenta development; IEA:Compara.
 GO:0006954; P:inflammatory response; IEA:Compara.
 GO:0060716; P:labyrinthine layer blood vessel development; IEA:Compara.
 GO:0001893; P:maternal placenta development; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0045792; P:negative regulation of cell size; IEA:Compara.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0046329; P:negative regulation of JNK cascade; IEA:Compara.
 GO:0006469; P:negative regulation of protein kinase activity; IEA:Compara.
 GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; IEA:Compara.
 GO:0001649; P:osteoblast differentiation; IEA:Compara.
 GO:0018105; P:peptidyl-serine phosphorylation; IEA:Compara.
 GO:0032287; P:peripheral nervous system myelin maintenance; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0030307; P:positive regulation of cell growth; IEA:Compara.
 GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Compara.
 GO:0010765; P:positive regulation of sodium ion transport; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045907; P:positive regulation of vasoconstriction; IEA:Compara.
 GO:0030163; P:protein catabolic process; IEA:Compara.
 GO:0043491; P:protein kinase B signaling cascade; IEA:Compara.
 GO:0016567; P:protein ubiquitination; IEA:Compara.
 GO:0030334; P:regulation of cell migration; IEA:Compara.
 GO:0010975; P:regulation of neuron projection development; IEA:Compara.
 GO:0032880; P:regulation of protein localization; IEA:Compara.
 GO:0032094; P:response to food; IEA:Compara.
 GO:0051146; P:striated muscle cell differentiation; IEA:Compara.
 GO:0006412; P:translation; IEA:Compara. 

Interpro

 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 

Pfam

 PF00169; PH 

SMART

 SM00233; PH 

PROSITE

 PS50003; PH_DOMAIN 

PRINTS