CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016222
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein kinase 32C 
Protein Synonyms/Alias
 PKE; Yet another novel kinase 3 
Gene Name
 STK32C 
Gene Synonyms/Alias
 YANK3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
218HIIHRDVKPDNILLDubiquitination[1]
364LWDHLSEKRVEPGFVubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
 DOMAIN 93 353 Protein kinase.
 NP_BIND 99 107 ATP (By similarity).
 ACT_SITE 216 216 Proton acceptor (By similarity).
 BINDING 122 122 ATP (By similarity).
 MOD_RES 15 15 Phosphoserine.
 MOD_RES 18 18 Phosphoserine.  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 486 AA 
Protein Sequence
MRSGAERRGS SAAASPGSPP PGRARPAGSD APSALPPPAA GQPRARDSGD VRSQPRPLFQ 60
WSKWKKRMGS SMSAATARRP VFDDKEDVNF DHFQILRAIG KGSFGKVCIV QKRDTEKMYA 120
MKYMNKQQCI ERDEVRNVFR ELEILQEIEH VFLVNLWYSF QDEEDMFMVV DLLLGGDLRY 180
HLQQNVQFSE DTVRLYICEM ALALDYLRGQ HIIHRDVKPD NILLDERGHA HLTDFNIATI 240
IKDGERATAL AGTKPYMAPE IFHSFVNGGT GYSFEVDWWS VGVMAYELLR GWRPYDIHSS 300
NAVESLVQLF STVSVQYVPT WSKEMVALLR KLLTVNPEHR LSSLQDVQAA PALAGVLWDH 360
LSEKRVEPGF VPNKGRLHCD PTFELEEMIL ESRPLHKKKK RLAKNKSRDN SRDSSQSEND 420
YLQDCLDAIQ QDFVIFNREK LKRSQDLPRE PLPAPESRDA AEPVEDEAER SALPMCGPIC 480
PSAGSG 486 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS