UniProt Accession

 ASPG1_YEAST; P38986; D6VSV3 

Genbank Protein ID

 Z27406; U32517; BK006938 

Genbank Nucleotide ID

 CAA81794.1; AAB64757.1; DAA12163.1 

Protein Name

 L-asparaginase 1 

Protein Synonyms/Alias

 L-asparaginase I; L-asparagine amidohydrolase I; ASP I 

Gene Name

 ASP1 

Gene Synonyms/Alias

 YDR321W; D9798.6 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
2	******MKSDSVEIT	ubiquitination	[1]
111	QLCNVDSKDINEDIL	ubiquitination	[1]
120	INEDILYKIYKGVSE	acetylation	[2]
321	SLPIVYSKRSMDGMV	ubiquitination	[1]
353	SGYLSPEKSRILLQL	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

  

Sequence Annotation

 REGION 141 142 Substrate binding (By similarity).
 ACT_SITE 64 64 O-isoaspartyl threonine intermediate (By
 BINDING 110 110 Substrate (By similarity).
 MOD_RES 350 350 Phosphoserine.  

Keyword

 Complete proteome; Cytoplasm; Hydrolase; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 381 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005622; C:intracellular; IC:SGD.
 GO:0004067; F:asparaginase activity; IMP:SGD.
 GO:0006530; P:asparagine catabolic process; IGI:SGD. 

Interpro

 IPR004550; AsnASE_II.
 IPR006034; Asparaginase/glutaminase.
 IPR020827; Asparaginase/glutaminase_AS1.
 IPR027475; Asparaginase/glutaminase_AS2.
 IPR027473; L-asparaginase_C.
 IPR027474; L-asparaginase_N. 

Pfam

 PF00710; Asparaginase 

SMART

 SM00870; Asparaginase 

PROSITE

 PS00144; ASN_GLN_ASE_1
 PS00917; ASN_GLN_ASE_2 

PRINTS

 PR00139; ASNGLNASE.