CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023554
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitochondrial ornithine transporter 1 
Protein Synonyms/Alias
 Solute carrier family 25 member 15 
Gene Name
 Slc25a15 
Gene Synonyms/Alias
 Ornt1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
36PFDTMKVKMQTFPDLacetylation[1]
36PFDTMKVKMQTFPDLubiquitination[2]
53GLTDCCLKTYSQVGFacetylation[1, 3]
245QVLSMTGKQTGLVRTacetylation[4]
245QVLSMTGKQTGLVRTsuccinylation[4]
245QVLSMTGKQTGLVRTubiquitination[2]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
 Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix. 
Sequence Annotation
 REPEAT 7 91 Solcar 1.
 REPEAT 104 197 Solcar 2.
 REPEAT 207 293 Solcar 3.  
Keyword
 Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 301 AA 
Protein Sequence
MKSNPAIQAA IDLTAGAAGG TACVLTGQPF DTMKVKMQTF PDLYRGLTDC CLKTYSQVGF 60
RGFYKGTSPA LIANIAENSV LFMCYGFCQQ VVRKVVGLDQ QAKLSDLQNA AAGSFASAFA 120
ALVLCPTELV KCRLQTMYEM ETSGKIAASQ NTVWSVVKEI FRKDGPLGFY HGLSSTLLRE 180
VPGYFFFFGG YELSRSFFAS GRSKDELGPV PLMLSGGFGG ICLWLAVYPV DCIKSRIQVL 240
SMTGKQTGLV RTFLSIVKNE GITALYSGLK PTMIRAFPAN GALFLAYEYS RKLMMNQLEA 300
W 301 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 
Interpro
 IPR018108; Mitochondrial_sb/sol_carrier.
 IPR023395; Mt_carrier_dom. 
Pfam
 PF00153; Mito_carr 
SMART
  
PROSITE
 PS50920; SOLCAR 
PRINTS