| Tag | Content |
|---|
| CPLM ID | CPLM-037809 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rho guanine nucleotide exchange factor 12 |
Protein Synonyms/Alias | |
Gene Name | ARHGEF12 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 481 | KIKQSMKKDKEGEEK | acetylation | [1] | | 483 | KQSMKKDKEGEEKGK | acetylation | [1] | | 488 | KDKEGEEKGKRRGFP | acetylation | [1] | | 490 | KEGEEKGKRRGFPSI | acetylation | [1] |
|
Reference | [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response. Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C. Mol Cell. 2012 Apr 27;46(2):212-25. [ PMID: 22424773] |
Functional Description | |
Sequence Annotation | |
Keyword | Complete proteome; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1441 AA |
Protein Sequence | MRAGVQTGDR IIKVNGTLVT HSNHLEVVKL IKSGSYVALT VQGRPPGSPQ IPLADSEVEP 60
SVIGHMSPIM TSPHSPGASG NMERITSPVL MGEENNVVHN QKVEILRKML QKEQERLQLL 120
QEDYNRTPAQ RLLKEIQEAK KHIPQLQEQL SKATGSAQDG AVVTPSRPLG DTLTVSEAET 180
DPGDVLGRTD CSSGDASRPS SDNADSPKSG PKERIYLEEN PEKSETIQDT DTQSLVGSPS 240
TRIAPHIIGA EDDDFGTEHE QINGQCSCFQ SIELLKSRPA HLAVFLHHVV SQFDPATLLC 300
YLYSDLYKHT NSKETRRIFL EFHQFFLDRS AHLKVSVPDE MSADLEKRRP ELIPEDLHRH 360
YIQTMQERVH PEVQRHLEDF RQKRSMGLTL AESELTKLDA ERDKDRLTLE KERTCAEQIV 420
AKIEEVLMTA QAVEEDKSST MQYVILMYMK HLGVKVKEPR NLEHKRGRIG FLPKIKQSMK 480
KDKEGEEKGK RRGFPSILGP PRRPSRHDNS AIGRAMELQK ARHPKHLSTP SSVSPEPQDS 540
AKLRQSGLAN EGTDAGYLPA NSMSSVASGA SFSQEGGKEN DTGSKQVGET SAPGDTLDGT 600
PRTLNTVFDF PPPPLDQVQE EECEVERVTE HGTPKPFRKF DSVAFGESQS EDEQFENDLE 660
TDPPNWQQLV SREVLLGLKP CEIKRQEVIN ELFYTERAHV RTLKVLDQVF YQRVSREGIL 720
SPSELRKIFS NLEDILQLHI GLNEQMKAVR KRNETSVIDQ IGEDLLTWFS GPGEEKLKHA 780
AATFCSNQPF ALEMIKSRQK KDSRFQTFVQ DAESNPLCRR LQLKDIIPTQ MQRLTKYPLL 840
LDNIAKYTEW PTEREKVKKA ADHCRQILNY VNQAVKEAEN KQRLEDYQRR LDTSSLKLSE 900
YPNVEELRNL DLTKRKMIHE GPLVWKVNRD KTIDLYTLLL EDILVLLQKQ DDRLVLRCHS 960
KILASTADSK HTFSPVIKLS TVLVRQVATD NKALFVISMS DNGAQIYELV AQTVSEKTVW 1020
QDLICRMAAS VKEQSTKPIP LPQSTPGEGD NDEEDPSKLK EEQHGISVTG LQSPDRDLGL 1080
ESTLISSKPQ SHSLSTSGKS EVRDLFVAER QFAKEQHTDG TLKEVGEDYQ IAIPDSHLPV 1140
SEERWALDAL RNLGLLKQLL VQQLGLTEKS VQEDWQHFPR YRTASQGPQT DSVIQNSENI 1200
KAYHSGEGHM PFRTGTGDIA TCYSPRTSTE SFAPRDSVGL APQDSQASNI LVMDHMIMTP 1260
EMPTMEPEGG LDDSGEHFFD AREAHSDENP SEGDGAVNKE EKDVNLRISG NYLILDGYDP 1320
VQESSTDEEV ASSLTLQPMT GIPAVESTHQ QQHSPQNTHS DGAISPFTPE FLVQQRWGAM 1380
EYSCFEIQSP SSCADSQSQI MEYIHKIEAD LEHLKKVEES YTILCQRLAG SALTDKHSDK 1440
S 1441 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:InterPro. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. GO:0035556; P:intracellular signal transduction; IEA:InterPro. GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |