UniProt Accession

 CENPP_HUMAN; Q6IPU0; B3KS17; Q5T9F8; Q5T9F9 

Genbank Protein ID

 AK092603; AL157827; AL157827; AL157827; AL136097; AL137848; AL137848; AL136097; AL157827; AL136097; AL137848; AL157827; BC071726 

Genbank Nucleotide ID

 BAG52579.1; CAI12591.1; CAI12592.1; CAI12594.1; CAI12594.1; CAI12594.1; CAI16699.1; CAI16699.1; CAI16699.1; CAI16210.1; CAI16210.1; CAI16210.1; AAH71726.1 

Protein Name

 Centromere protein P 

Protein Synonyms/Alias

 CENP-P 

Gene Name

 CENPP 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
32	PPAPWEEKSRVQKSF	ubiquitination	[1, 2]
37	EEKSRVQKSFQAIHQ	ubiquitination	[3, 4]
83	INIRNHSKQTEDLTS	ubiquitination	[1]
96	TSTEMTEKSIRKVLQ	ubiquitination	[1, 2]
251	QRALELDKNRAIETA	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. 

Sequence Annotation

  

Keyword

 Centromere; Chromosome; Coiled coil; Complete proteome; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 288 AA 

Protein Sequence

Gene Ontology

 GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0034080; P:CENP-A containing nucleosome assembly at centromere; TAS:Reactome.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome. 

Interpro

  

Pfam

  

SMART

  

PROSITE

  

PRINTS