CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043778
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Lanosterol 14-alpha demethylase 
Protein Synonyms/Alias
  
Gene Name
 CYP51A1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
8XRAHREIKDIFYKAIubiquitination[1, 2, 3]
13EIKDIFYKAIQKRRQubiquitination[1, 2, 3, 4]
24KRRQSQEKIDDILQTubiquitination[3]
89KKCYLEQKTVCGENLubiquitination[2, 4]
105PLTYDQLKDLNLLDRubiquitination[2, 4]
115NLLDRCIKETLRLRPubiquitination[5]
155DNPASGEKFAYVPFGubiquitination[3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 222 AA 
Protein Sequence
XRAHREIKDI FYKAIQKRRQ SQEKIDDILQ TLLDATYKDG RPLTDDEVAG MLIGLLLAGQ 60
HTSSTTSAWM GFFLARDKTL QKKCYLEQKT VCGENLPPLT YDQLKDLNLL DRCIKETLRL 120
RPPIMIMMRM ARTPQTVAGY TIPPGHQDNP ASGEKFAYVP FGAGRHRCIG ENFAYVQIKT 180
IWSTMLRLYE FDLIDGYFPT VNYTTMIHTP ENPVIRYKRR SK 222 
Gene Ontology
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
 GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002403; Cyt_P450_E_grp-IV. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00465; EP450IV.
 PR00385; P450.