CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024451
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 NACHT and WD repeat domain-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 Nwd1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
711KPLNLDRKVAPQPLWubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
 REPEAT 274 314 WD 1.
 DOMAIN 336 666 NACHT.
 REPEAT 866 905 WD 2.
 REPEAT 908 947 WD 3.
 REPEAT 954 994 WD 4.
 REPEAT 998 1037 WD 5.
 REPEAT 1044 1082 WD 6.
 REPEAT 1126 1165 WD 7.
 REPEAT 1168 1207 WD 8.
 REPEAT 1212 1251 WD 9.
 REPEAT 1253 1292 WD 10.
 REPEAT 1346 1385 WD 11.
 REPEAT 1386 1425 WD 12.
 REPEAT 1431 1470 WD 13.
 NP_BIND 342 349 ATP (Potential).  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1563 AA 
Protein Sequence
MDTEREALQC TAYPEVQSFC QRHGLAFEVV DLRWGIPNTQ ATDYLTTELC LEELERCQKT 60
SIGPAFVALL GDQYGPCPVP RRIEEKEWEA LRAQLTSRPR DLELVTRHFQ RDDNTIPPTY 120
VLQPSGSLVV PGPEEATLTS VLRGGAQEAW RLGLISQEQW MCYHRSVIEW EIELGLLSSA 180
RGDQGATVFL RDVQDLNKHI LDDCSLKMVD RLVDGCLDTN AQSLLSGLKG RILDAQPGAL 240
KSHHLSWSRD LVNPKNKAHA RYLKQLSEQF VARTNHQVLE QLRELELARQ ELGWLYQEIR 300
HHLWQSTEST KVFCGHQELL AQLRQQLRQD ESRTHTPLVL FGPPGIGKTS LMCKLAQQVP 360
ELLGHKTVVV LRLLGTSKLS LDARSLLRSL SFQVCLAYGL PLPPAQVLEA HSRVGHFFHT 420
LLHTVSQRNF ESLVLLLDSV DDLDSICHSP RVSWLPLKCP PRVHLILSTC SGQQVLHNLQ 480
QTLKDPSTYW EVKALSGSQG QEFIQLLLAA EKRMLSPGQR DVLWASLPEC GHPGRLRLAF 540
EEARKWASFT VPVPLATTAE EATHQLCIRL EETHGALLVA HVLGYIVSSR YGLSEAELKD 600
VLSLDDEVLQ AVYRDWTPPS KELLRFPPLL WVRLRRDLGH CLVRRPVDGC MLLAIAHRQL 660
SQVIQVRYLS GPERAKRHGV LAEFFSGAWS QGIKKLITLP LVGKPLNLDR KVAPQPLWFS 720
STVANLRKLT ELPFHLLHAG RLEELKQEVL GNMSWISCRG ISGGIEVLLD DFDMCAPHMN 780
SPEVDLVREA IQLCGPAVEL RGLEKSVLYT ELLARLLFFA ASHPAMIGQL CQQAQSWFRA 840
CPYPMLVPLA GFLQPPGGPL RATLTGCHKG ITAIAWSLEE KLLVVGTQDG AMVVWDVEEQ 900
QVVHVLMGHT AEVKCVRVFA QGTLAISASK DHTLRLWSLL SGQEKVTILD GGSQNPTEPQ 960
SWDLHVDERN NVVYSTSGAR INMWNLETSK LVFCITGDVS DPWVCVALLA AQGLLLALSK 1020
GGQVSLWSSA MGKLQEKHQL SSIKEETPTC AVSIQSRARL VAGFSSGSIA LVSAGEDRLL 1080
EKLPEAVGFL VVSEDDSLLV AGFGRFVRIF LADSQGFHRF MASDLEHEDM VETAVLGPEN 1140
NLIITGSRDA LIQVWSLSEQ GTLLNVLEGV GAPVSLLVRG GTLVVSASRK SSSFKVWDLK 1200
STKKLQSPTP FLDRTGLAAV SHHGSFVYFP KVGDKNKVTI WDLAEGEEQD CLDTSNEVRC 1260
LEVAEQAKLL FTGLVSGIVL VFPLNSRQDV LCIPPPEARK AVNCMSLSKS ENRLAIAYDN 1320
IVLVLDISPG DPCPAIEGPT YTFYTQLPET IVSVAVLADY RVVYGMSDGS LFLYDCACSK 1380
VFPLEAHGSR VSCVEVSHSE QLAVSGAEDA LLCLWDLQAC RGMFEMSYEN SCCRGVRCAC 1440
FSRDDKHVFA GMEDRSVTAW STVDGTLLAV QFVHAVINRI IPTSNGFMAP TSHGYLIRER 1500
FQCPSVRASQ QDPLKNFKKA VWLVKTRQRE ELAAAEASQD AEPVAVEGKE SKSNKRSQVC 1560
LIL 1563 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS50837; NACHT
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS