CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031433
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 cDNA FLJ59571, highly similar to Eukaryotic translation initiation factor 4gamma 2 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
114GNSEFLGKTPGQNAQubiquitination[1]
144ANNSANEKERHDAIFubiquitination[2]
231AEGQPGQKQSTTFRRubiquitination[2]
243FRRLLISKLQDEFENubiquitination[1, 2]
260RNVDVYDKRENPLLPubiquitination[1, 2]
501QFGEMGGKFMKSQGLubiquitination[3]
504EMGGKFMKSQGLSQLubiquitination[3, 4]
648VREMRAPKHFLPEMLubiquitination[3]
812KLEKELLKQIKLDPSubiquitination[3]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
 Initiation factor; Protein biosynthesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 980 AA 
Protein Sequence
MAGWPTPAGT RPWRTEARLC SDGEGAWLGP LAPWREARLA SRRGGISFLL SPPLPTPSIN 60
IILLKILRCQ AAKVESAIAE GGASRFSASS GGGGSRGAPQ HYPKTAGNSE FLGKTPGQNA 120
QKWIPARSTR RDDNSAANNS ANEKERHDAI FRKVRGILNK LTPEKFDKLC LELLNVGVES 180
KLILKGVILL IVDKALEEPK YSSLYAQLCL RLAEDAPNFD GPAAEGQPGQ KQSTTFRRLL 240
ISKLQDEFEN RTRNVDVYDK RENPLLPEEE EQRAIAKIKM LGNIKFIGEL GKLDLIHESI 300
LHKCIKTLLE KKKRVQLKDM GEDLECLCQI MRTVGPRLDH ERAKSLMDQY FARMCSLMLS 360
KELPARIRFL LQDTVELREH HWVPRKAFLD NGPKTINQIR QDAVKDLGVF IPAPMAQGMR 420
SDFFLEGPFM PPRMKMDRDP LGGLADMFGQ MPGSGIGTGP GVIQDRFSPT MGRHRSNQLF 480
NGHGGHIMPP TQSQFGEMGG KFMKSQGLSQ LYHNQSQGLL SQLQGQSKDM PPRFSKKGQL 540
NADEISLRPA QSFLMNKNQV PKLQPQITMI PPSAQPPRTQ TPPLGQTPQL GLKTNPPLIQ 600
EKPAKTSKKP PPSKEELLKL TETVVTEYLN SGNANEAVNG VREMRAPKHF LPEMLSKVII 660
LSLDRSDEDK EKASSLISLL KQEGIATSDN FMQAFLNVLD QCPKLEVDIP LVKSYLAQFA 720
ARAIISELVS ISELAQPLES GTHFPLFLLC LQQLAKLQDR EWLTELFQQS KVNMQKMLPE 780
IDQNKDRMLE ILEGKGLSFL FPLLKLEKEL LKQIKLDPSP QTIYKWIKDN ISPKLHVDKG 840
FVNILMTSFL QYISSEVNPP SDETDSSSAP SKEQLEQEKQ LLLSFKPVMQ KFLHDHVDLQ 900
VSALYALQVH CYNSNFPKGM LLRFFVHFYD MEIIEEEAFL AWKEDITQEF PGKGKALFQV 960
NQWLTWLETA EEEESEEEAD 980 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
 GO:0016070; P:RNA metabolic process; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR003891; Initiation_fac_eIF4g_MI.
 IPR016021; MIF4-like_typ_1/2/3.
 IPR003890; MIF4G-like_typ-3.
 IPR003307; W2_domain. 
Pfam
 PF02847; MA3
 PF02854; MIF4G
 PF02020; W2 
SMART
 SM00515; eIF5C
 SM00544; MA3
 SM00543; MIF4G 
PROSITE
 PS51366; MI
 PS51363; W2 
PRINTS