CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031113
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Histone deacetylase 8 
Protein Synonyms/Alias
 cDNA FLJ58211, highly similar to Histone deacetylase 8 
Gene Name
 HDAC8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
175QQILNYIKGNLKHVVubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 182 AA 
Protein Sequence
MTVSLHKFSP GFFPGTGDVS DVGLGKGRYY SVNVPIQDGI QDEKYYQICE SVLKEVYQAF 60
NPKAVVLQLG ADTIAGDPMC SFNMTPVGIG KCLKYILQWQ LATLILGGGG YNLANTARCW 120
TYLTGVILGK TLSSEIPDHE FFTAYGPDYV LEITPSCRPD RNEPHRIQQI LNYIKGNLKH 180
VV 182 
Gene Ontology
 GO:0004407; F:histone deacetylase activity; IEA:InterPro. 
Interpro
 IPR000286; His_deacetylse.
 IPR003084; His_deacetylse_1.
 IPR023801; His_deacetylse_dom. 
Pfam
 PF00850; Hist_deacetyl 
SMART
  
PROSITE
  
PRINTS
 PR01271; HISDACETLASE.