UniProt Accession

 RL38_MOUSE; Q9JJI8 

Genbank Protein ID

 AB037665; AK002659; AK010277; AK010518; AK012391; BC055346 

Genbank Nucleotide ID

 BAB03500.1; BAB22266.1; BAB26814.1; BAB27000.1; BAB28208.1; AAH55346.1 

Protein Name

 60S ribosomal protein L38 

Protein Synonyms/Alias

  

Gene Name

 Rpl38 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
4	****MPRKIEEIKDF	acetylation	[1]
4	****MPRKIEEIKDF	ubiquitination	[2]
9	PRKIEEIKDFLLTAR	acetylation	[1, 3]
9	PRKIEEIKDFLLTAR	ubiquitination	[2]
29	SVKIKKNKDNVKFKV	acetylation	[3]
50	YTLVITDKEKAEKLK	ubiquitination	[2]
52	LVITDKEKAEKLKQS	acetylation	[3]
55	TDKEKAEKLKQSLPP	acetylation	[3]
67	LPPGLAVKDLK****	acetylation	[1, 4, 5, 6]
67	LPPGLAVKDLK****	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [6] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

  

Sequence Annotation

 MOD_RES 9 9 N6-acetyllysine (By similarity).
 MOD_RES 67 67 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Reference proteome; Ribonucleoprotein; Ribosomal protein. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 70 AA 

Protein Sequence

Gene Ontology

 GO:0022625; C:cytosolic large ribosomal subunit; IEA:Compara.
 GO:0033291; C:eukaryotic 80S initiation complex; IDA:MGI.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0034463; P:90S preribosome assembly; IDA:MGI.
 GO:0048318; P:axial mesoderm development; IMP:MGI.
 GO:0042474; P:middle ear morphogenesis; IMP:MGI.
 GO:0001503; P:ossification; IMP:MGI.
 GO:0006417; P:regulation of translation; IMP:MGI.
 GO:0007605; P:sensory perception of sound; IMP:MGI.
 GO:0001501; P:skeletal system development; IMP:MGI.
 GO:0006412; P:translation; IEA:InterPro. 

Interpro

 IPR002675; Ribosomal_L38e. 

Pfam

 PF01781; Ribosomal_L38e 

SMART

  

PROSITE

  

PRINTS