CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037306
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 CUGBP Elav-like family member 2 
Protein Synonyms/Alias
  
Gene Name
 CELF2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
61IPRSWSEKELKELFEubiquitination[1, 2]
90SQNPPQSKGCCFVTFubiquitination[1, 2, 3]
101FVTFYTRKAALEAQNubiquitination[1, 2]
132MKPADSEKSNAVEDRubiquitination[1]
197AMAQNAIKAMHQSQTubiquitination[1]
221VKFADTQKDKEQRRLubiquitination[1]
223FADTQKDKEQRRLQQubiquitination[1]
471SAKVFIDKQTNLSKCubiquitination[1, 4, 5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 521 AA 
Protein Sequence
MTSAFKLDFL PDMMVEGRLL VPDRINGTAN KMNGALDHSD QPDPDAIKMF VGQIPRSWSE 60
KELKELFEPY GAVYQINVLR DRSQNPPQSK GCCFVTFYTR KAALEAQNAL HNIKTLPGMH 120
HPIQMKPADS EKSNAVEDRK LFIGMVSKKC NENDIRVMFS PFGQIEECRI LRGPDGLSRG 180
CAFVTFSTRA MAQNAIKAMH QSQTMEGCSS PIVVKFADTQ KDKEQRRLQQ QLAQQMQQLN 240
TATWGNLTGL GGLTPQYLAL LQQATSSSNL GAFSGIQQMA GMNALQLQNL ATLAAAAAAA 300
QTSATSTNAN PLSTTSSALG ALTSPVAAST PNSTAGAAMN SLTSLGTLQG LAGATVGLNN 360
INALAVAQML SGMAALNGGL GATGLTNGTA GTMDALTQAY SGIQQYAAAA LPTLYSQSLL 420
QQQSAAGSQK EGPEGANLFI YHLPQEFGDQ DILQMFMPFG NVISAKVFID KQTNLSKCFG 480
FVSYDNPVSA QAAIQAMNGF QIGMKRLKVQ LKRSKNDSKP Y 521 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006376; P:mRNA splice site selection; IEA:Compara. 
Interpro
 IPR002343; Hud_Sxl_RNA.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS
 PR00961; HUDSXLRNA.