| Tag | Content |
|---|
| CPLM ID | CPLM-009157 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Solute carrier family 12 member 3 |
Protein Synonyms/Alias | Na-Cl symporter; Thiazide-sensitive sodium-chloride cotransporter |
Gene Name | Slc12a3 |
Gene Synonyms/Alias | Tsc |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 79 | ALPGEPRKVRPTLAD | ubiquitination | [1] | | 126 | ETGTNSEKSPGEPVR | ubiquitination | [1] | | 197 | ISTNGKVKSGGTYFL | ubiquitination | [1] | | 704 | WLNKRKIKAFYSDVI | ubiquitination | [1] | | 809 | IFQSEQGKKTIDIYW | ubiquitination | [1] | | 858 | NRMDEERKAIISLLS | ubiquitination | [1] | | 883 | VLPDINQKPQAEHTK | ubiquitination | [1] | | 890 | KPQAEHTKRFEDMIA | ubiquitination | [1] | | 906 | FRLNDGFKDEATVTE | ubiquitination | [1] | | 921 | MRRDCPWKISDEEIN | ubiquitination | [1] | | 929 | ISDEEINKNRIKSLR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Electrically silent transporter system. Mediates sodium and chloride reabsorption (By similarity). |
Sequence Annotation | CARBOHYD 404 404 N-linked (GlcNAc...) (Potential).
CARBOHYD 424 424 N-linked (GlcNAc...) (Potential).
CARBOHYD 542 542 N-linked (GlcNAc...) (Potential).
CARBOHYD 779 779 N-linked (GlcNAc...) (Potential). |
Keyword | Cell membrane; Complete proteome; Glycoprotein; Ion transport; Membrane; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1002 AA |
Protein Sequence | MAELPVTELP GDALCSGRFT ISTLMGGDEP PPAACDSSQP SHLTHGSTLY MRTFGYNTID 60
VVPAYEHYAN SALPGEPRKV RPTLADLHSF LKQEGSHLHA LAFDGRQGRE LTDGLVEDET 120
GTNSEKSPGE PVRFGWVKGV MIRCMLNIWG VILYLRLPWI TAQAGIVLTW LIILLSVMVT 180
SITGLSISAI STNGKVKSGG TYFLISRSLG PELGGSIGLI FAFANAVGVA MHTVGFAETV 240
RDLLQEYGTP IVDPINDIRI IGVVTVTVLL AISLAGMEWE SKAQVLFFLV IMVSFANYLV 300
GTLIPASEDK ASKGFYSYHG DIFVQNLVPD WRGIDGSFFG MFSIFFPSAT GILAGANISG 360
DLKDPAVAIP KGTLMAIFWT TISYLAISAT IGSCVVRDAS GDVNDTMTPG PGPCEGLACG 420
YGWNFTECSQ QRSCRYGLIN YYQTMSMVSA FAPLITAGIF GATLSSALAC LVSAAKVFQC 480
LCEDQLYPLI GFFGKGYGKN REPVRGYLLA YAIAVAFIII AELNTIAPII SNFFLCSYAL 540
INFSCFHASI TNSPGWRPSF RYYSKWAALF GAVISVVIMF LLTWWAALIA IGVVLFLLLY 600
VIYKKPEVNW GSSVQAGSYN LALSYSVGLN EVEDHIKNYR PQCLVLTGPP NFRPALVDFV 660
STFTQNLSLM ICGHVLIGPG KQRVPELRLI ASGHTKWLNK RKIKAFYSDV IAEDLRSGVQ 720
ILMQASGLGR MKPNILVVGF KRNWQSAHPA TVEDYIGVLH DAFDFNYGVC VMRMREGLNV 780
SEALQTHTTP EALIQEEQAS TIFQSEQGKK TIDIYWLFDD GGLTLLIPYL LHRKKRWGKC 840
KIRVFVGGQI NRMDEERKAI ISLLSKFRLG FHEVHVLPDI NQKPQAEHTK RFEDMIAPFR 900
LNDGFKDEAT VTEMRRDCPW KISDEEINKN RIKSLRQVRL SEILLDYSRD AALIILTLPI 960
GRKGKCPSSL YMAWLETLSQ DLRPPVLLIR GNQENVLTFY CQ 1002 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IDA:UniProtKB. GO:0005829; C:cytosol; IDA:UniProtKB. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0015377; F:cation:chloride symporter activity; IEA:InterPro. GO:0005215; F:transporter activity; IDA:UniProtKB. GO:0006814; P:sodium ion transport; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |