UniProt Accession

 CIP4_HUMAN; Q15642; B2R8A6; B7WP22; D6W645; O15184; Q53G22; Q5TZN1; Q6FI24; Q8NFL1; Q8TCY1; Q8TDX3; Q96RJ1 

Genbank Protein ID

 AJ000414; AF380114; AY081141; AB072596; AF502289; CR536513; BT006698; BT020167; BT020171; AK223109; AK313296; AC008760; CH471139; CH471139; CH471139; BC013002; L40379 

Genbank Nucleotide ID

 CAA04062.1; AAK77492.1; AAL89588.1; BAB88853.1; AAM46851.1; CAG38751.1; AAP35344.1; AAV38969.1; AAV43773.1; BAD96829.1; BAG36103.1; EAW69065.1; EAW69062.1; EAW69063.1; AAH13002.1; AAC41729.1 

Protein Name

 Cdc42-interacting protein 4 

Protein Synonyms/Alias

 Protein Felic; Salt tolerant protein; hSTP; Thyroid receptor-interacting protein 10; TR-interacting protein 10; TRIP-10 

Gene Name

 TRIP10 

Gene Synonyms/Alias

 CIP4; STOT; STP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
44	EVEQAYAKQLRSLVK	ubiquitination	[1]
66	AKDDPESKFSQQQSF	ubiquitination	[1]
166	DQDINATKADVEKAK	ubiquitination	[1]
187	SHMAEESKNEYAAQL	ubiquitination	[1]
215	QMPQIFDKLQDMDER	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N- WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. 

Sequence Annotation

 DOMAIN 1 65 FCH.
 REPEAT 405 481 REM.
 DOMAIN 540 601 SH3.
 REGION 1 288 F-BAR domain.
 REGION 1 117 Required for podosome formation and
 REGION 1 117 Required for translocation to the plasma
 REGION 293 601 Interaction with PDE6G (By similarity).
 REGION 293 537 Interaction with CDC42.
 REGION 471 601 Required for interaction with FASLG and
 REGION 487 541 Interaction with DNM2 and WASL (By
 REGION 529 601 Interaction with DNM1 and WASL.
 REGION 538 601 Required for podosome formation.
 REGION 544 601 Interaction with WAS.
 REGION 546 601 Interaction with ARHGAP17, DAAM1, DIAPH1
 MOD_RES 296 296 Phosphoserine.
 MOD_RES 299 299 Phosphoserine.
 MOD_RES 335 335 Phosphoserine.
 MOD_RES 351 351 Phosphoserine.
 MOD_RES 482 482 Phosphoserine.  

Keyword

 3D-structure; Alternative splicing; Cell membrane; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Endocytosis; Golgi apparatus; Lipid-binding; Lysosome; Membrane; Phosphoprotein; Reference proteome; SH3 domain. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 601 AA 

Protein Sequence

Gene Ontology

 GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
 GO:0042995; C:cell projection; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0001891; C:phagocytic cup; IEA:UniProtKB-SubCell.
 GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
 GO:0030036; P:actin cytoskeleton organization; NAS:UniProtKB.
 GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
 GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.
 GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. 

Interpro

 IPR001060; FCH_dom.
 IPR001452; SH3_domain. 

Pfam

 PF00611; FCH
 PF00018; SH3_1 

SMART

 SM00055; FCH
 SM00326; SH3 

PROSITE

 PS50133; FCH
 PS50002; SH3 

PRINTS