CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024041
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 MAU2 chromatid cohesion factor homolog 
Protein Synonyms/Alias
 MAU-2; Cohesin loading complex subunit SCC4 homolog 
Gene Name
 MAU2 
Gene Synonyms/Alias
 KIAA0892; SCC4 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
91QARSHLEKAWLISQQubiquitination[1, 2]
315KAQKYTDKALMQLEKubiquitination[3]
322KALMQLEKLKMLDCSubiquitination[1, 2]
479QGRYNEAKRFLRETLubiquitination[3]
487RFLRETLKMSNAEDLubiquitination[3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Required for association of the cohesin complex with chromatin during interphase. Plays a role in sister chromatid cohesion and normal progression through prometaphase. 
Sequence Annotation
 REPEAT 107 140 TPR 1.
 REPEAT 379 412 TPR 2.
 REPEAT 459 492 TPR 3.
 REPEAT 499 532 TPR 4.
 REGION 1 115 Sufficient for interaction with NIPBL.  
Keyword
 Alternative splicing; Cell cycle; Cell division; Chromosome partition; Complete proteome; Mitosis; Nucleus; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 613 AA 
Protein Sequence
MAAQAAAAAQ AAAAQAAQAE AADSWYLALL GFAEHFRTSS PPKIRLCVHC LQAVFPFKPP 60
QRIEARTHLQ LGSVLYHHTK NSEQARSHLE KAWLISQQIP QFEDVKFEAA SLLSELYCQE 120
NSVDAAKPLL RKAIQISQQT PYWHCRLLFQ LAQLHTLEKD LVSACDLLGV GAEYARVVGS 180
EYTRALFLLS KGMLLLMERK LQEVHPLLTL CGQIVENWQG NPIQKESLRV FFLVLQVTHY 240
LDAGQVKSVK PCLKQLQQCI QTISTLHDDE ILPSNPADLF HWLPKEHMCV LVYLVTVMHS 300
MQAGYLEKAQ KYTDKALMQL EKLKMLDCSP ILSSFQVILL EHIIMCRLVT GHKATALQEI 360
SQVCQLCQQS PRLFSNHAAQ LHTLLGLYCV SVNCMDNAEA QFTTALRLTN HQELWAFIVT 420
NLASVYIREG NRHQEVLYSL LERINPDHSF PVSSHCLRAA AFYVRGLFSF FQGRYNEAKR 480
FLRETLKMSN AEDLNRLTAC SLVLLGHIFY VLGNHRESNN MVVPAMQLAS KIPDMSVQLW 540
SSALLRDLNK ACGNAMDAHE AAQMHQNFSQ QLLQDHIEAC SLPEHNLITW TDGPPPVQFQ 600
AQNGPNTSLA SLL 613 
Gene Ontology
 GO:0000785; C:chromatin; IDA:UniProtKB.
 GO:0005654; C:nucleoplasm; IDA:UniProtKB.
 GO:0032116; C:SMC loading complex; IDA:UniProtKB.
 GO:0000910; P:cytokinesis; TAS:Reactome.
 GO:0034088; P:maintenance of mitotic sister chromatid cohesion; IMP:UniProtKB.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome. 
Interpro
 IPR019440; Cohesin_loading_factor.
 IPR011990; TPR-like_helical. 
Pfam
 PF10345; Cohesin_load 
SMART
  
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS