UniProt Accession

 OSGEP_HUMAN; Q9NPF4; Q6IAC3 

Genbank Protein ID

 AB047823; AB050442; AJ271669; AK000418; CR457232; BC032310 

Genbank Nucleotide ID

 BAB33147.1; BAB33172.1; CAB71031.1; BAA91150.1; CAG33513.1; AAH32310.1 

Protein Name

 Probable tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP 

Protein Synonyms/Alias

 hOSGEP; t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP 

Gene Name

 OSGEP 

Gene Synonyms/Alias

 GCPL1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
13	GFEGSANKIGVGVVR	ubiquitination	[1]
23	VGVVRDGKVLANPRR	ubiquitination	[1]
169	DRFARVLKISNDPSP	ubiquitination	[1, 2]
185	YNIEQMAKRGKKLVE	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity). 

Sequence Annotation

 METAL 109 109 Iron (By similarity).
 METAL 113 113 Iron (By similarity).
 METAL 130 130 Iron (By similarity).
 METAL 294 294 Iron (By similarity).  

Keyword

 Complete proteome; Iron; Metal-binding; Reference proteome; tRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 335 AA 

Protein Sequence

Gene Ontology

 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008033; P:tRNA processing; IEA:UniProtKB-KW. 

Interpro

 IPR000905; Gcp-like_dom.
 IPR017861; KAE1/YgjD.
 IPR017860; Peptidase_M22_CS. 

Pfam

 PF00814; Peptidase_M22 

SMART

  

PROSITE

 PS01016; GLYCOPROTEASE 

PRINTS

 PR00789; OSIALOPTASE.