CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013847
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aldose reductase-related protein 1 
Protein Synonyms/Alias
 Aldehyde reductase; Aldo-keto reductase family 1 member B7; Aldose reductase-like protein AKR1B14 
Gene Name
 Akr1b7 
Gene Synonyms/Alias
 Akr1b14 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
6**MTTFVKLRTKAKMacetylation[1]
90FFEKSLMKEAFQKTLacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. May play a role in the metabolism of xenobiotic aromatic aldehydes. 
Sequence Annotation
 NP_BIND 20 21 NADP.
 NP_BIND 160 161 NADP.
 NP_BIND 210 215 NADP.
 NP_BIND 263 269 NADP.
 ACT_SITE 49 49 Proton donor (By similarity).
 BINDING 44 44 NADP.
 BINDING 184 184 NADP.
 BINDING 273 273 NADP.  
Keyword
 3D-structure; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 316 AA 
Protein Sequence
MTTFVKLRTK AKMPLVGLGT WKSPPGQVKE AVKAAIDAGY RHFDCAYVYQ NESEVGEAIQ 60
EKIKEKAVRR EDLFIVSKLW STFFEKSLMK EAFQKTLSDL KLDYLDLYLI HWPQGLQAGK 120
EFLPKDSQGK VLMSKSTFLD AWEGMEELVD QGLVKALGVS NFNHFQIERL LNKPGLKHKP 180
VTNQVECHPY LTQEKLIQYC HSKGIAVIAY SPLGSPDRPY AKPEDPVVLE IPKIKEIAAK 240
HKKTIAQVLI RFHVQRNVAV IPKSVTLSHI KENIQVFDFQ LSEEDMAAIL SLNRNWRACG 300
LFVTSDEEDF PFHEEY 316 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; TAS:RGD. 
Interpro
 IPR001395; Aldo/ket_red.
 IPR018170; Aldo/ket_reductase_CS.
 IPR020471; Aldo/keto_reductase_subgr.
 IPR023210; NADP_OxRdtase_dom. 
Pfam
 PF00248; Aldo_ket_red 
SMART
  
PROSITE
 PS00798; ALDOKETO_REDUCTASE_1
 PS00062; ALDOKETO_REDUCTASE_2 
PRINTS
 PR00069; ALDKETRDTASE.