| Tag | Content |
|---|
| CPLM ID | CPLM-013814 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Store-operated calcium entry-associated regulatory factor |
Protein Synonyms/Alias | SARAF; SOCE-associated regulatory factor; Transmembrane protein 66 |
Gene Name | TMEM66 |
Gene Synonyms/Alias | SARAF |
Created Date | July 27, 2013 |
Organism | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
NCBI Taxa ID | 9601 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 106 | TDLDIAYKFGKTVVS | ubiquitination | [1] |
|
Reference | [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C. Nat Cell Biol. 2012 Oct;14(10):1089-98. [ PMID: 23000965] |
Functional Description | Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)- dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions (By similarity). |
Sequence Annotation | |
Keyword | Calcium; Calcium transport; Complete proteome; Endoplasmic reticulum; Ion transport; Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 339 AA |
Protein Sequence | MASACGPGAA GHCLLLGLHL FLLTAGPALG WNDPECMLLR DVKALTLHYD RYTTSRRLDP 60
IPQLKCVGGT AGCDSYTPKV IQCQNKGWDG YDVQWECKTD LDIAYKFGKT VVSCEGYESS 120
EDQYVLRGSC GLEYNLDYTE LGLQKLKESG KQHGFASFSD YYYKWYSADS CNMSGLITIV 180
VLLGIAFVVY KLFLSDGQYS PPPYSEYPPF SHRYQRFTNS AGPPPPGFKS EFTGPQNTGH 240
GATSGFGSAF TGQQGYENSG PGFWTGLGTG GILGYLFGSN RAATPFSDSW YYPSYPPSYP 300
GTWNRAYSPL RGGSGSYSAC SNSDTKTRTA SGYGGTRRR 339 |
Gene Ontology | GO:0030176; C:integral to endoplasmic reticulum membrane; ISS:UniProtKB. GO:0015279; F:store-operated calcium channel activity; ISS:UniProtKB. GO:2001256; P:regulation of store-operated calcium entry; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |