UniProt Accession

 CP1B1_HUMAN; Q16678; Q5TZW8; Q93089; Q9H316 

Genbank Protein ID

 U03688; U56438; AF450132; AF450131; BT019979; AY393998; BC012049; AF171066 

Genbank Nucleotide ID

 AAA19567.1; AAC50809.1; AAM50512.1; AAM50512.1; AAV38782.1; AAQ87875.1; AAH12049.1; AAG43404.1 

Protein Name

 Cytochrome P450 1B1 

Protein Synonyms/Alias

 CYPIB1 

Gene Name

 CYP1B1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
142	GHYSEHWKVQRRAAH	ubiquitination	[1, 2, 3]
275	FSNFILDKFLRHCES	ubiquitination	[1, 2, 3, 4]
302	AFILSAEKKAAGDSH	ubiquitination	[2]
303	FILSAEKKAAGDSHG	ubiquitination	[2]
448	DPARFLDKDGLINKD	ubiquitination	[1, 2, 3]
454	DKDGLINKDLTSRVM	ubiquitination	[2]
467	VMIFSVGKRRCIGEE	ubiquitination	[2]
539	AVQNLQAKETCQ***	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. 

Sequence Annotation

 METAL 470 470 Iron (heme axial ligand).  

Keyword

 3D-structure; Complete proteome; Disease mutation; Endoplasmic reticulum; Glaucoma; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Peters anomaly; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 543 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0070330; F:aromatase activity; IEA:EC.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IDA:UniProtKB.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IDA:MGI.
 GO:0019825; F:oxygen binding; TAS:UniProtKB.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0006725; P:cellular aromatic compound metabolic process; IEA:Compara.
 GO:0043542; P:endothelial cell migration; IEA:Compara.
 GO:0071603; P:endothelial cell-cell adhesion; IEA:Compara.
 GO:0019373; P:epoxygenase P450 pathway; TAS:Reactome.
 GO:0097267; P:omega-hydroxylase P450 pathway; TAS:Reactome.
 GO:0009636; P:response to toxic substance; IEA:Compara.
 GO:0061298; P:retina vasculature development in camera-type eye; IEA:Compara.
 GO:0008202; P:steroid metabolic process; IDA:UniProtKB.
 GO:0009404; P:toxin metabolic process; IEA:Compara.
 GO:0007601; P:visual perception; TAS:UniProtKB.
 GO:0006805; P:xenobiotic metabolic process; IDA:UniProtKB. 

Interpro

 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I. 

Pfam

 PF00067; p450 

SMART

  

PROSITE

 PS00086; CYTOCHROME_P450 

PRINTS

 PR00463; EP450I.
 PR00385; P450.