CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044071
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 E3 ubiquitin-protein ligase UBR5 
Protein Synonyms/Alias
  
Gene Name
 Ubr5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
813LRELLSAKDARGMTPubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ligase; Reference proteome; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2503 AA 
Protein Sequence
VLLLPLERDS ELLRERESVL RLRERRWLDG ASFDNERGST SKEGEPNPDK KNTPVQSPVS 60
LGEDLQWWPD KDGTKFTCIG ALYSELVAVS SKGELYQWKW TESEPYRNAQ NPSLHHPRAT 120
FLGLTNEKIV LLSANSIRAT VATENNKVAT WVDETLSSVA SKLEHTAQTY SELQGERIVS 180
LHCCALYTCA QLENNLYWCH VIKFHESTKR IKKRRRSTPA PKEEEKVQSL NVRGGRQVCL 240
RNNPLYHAGA VAFSISAGIP KVGVLMESVW NMNDSCRFQL RSPESLKSME KASKTIETKP 300
ESKQEPVKTE MGPPPSPAST CSDASSIASS ASMPYILRRM KGIPSESSQA KGKKEFLLSA 360
SFLKSTASMD VVQVLKVDGA YVAVKFPGTS SNTNCQNSSG PDADPSSLLQ DCRLLRIDEL 420
QVVKTGGTPK VPDCFQRTPK KLCIPEKTEI LAVNVDSKGV HAVLKTGNWV RYCIFDLATG 480
KAEQENNFPT SSVAFLGQNE RSVAIFTAGQ ESPIILRDGN GTIYPMAKDC MGGIRDPDWL 540
DLPPISSLGM GVHSLINLPA NSTIKKKAAI IIMAVEKQTL MQHILRCDYE ACRQYLVNLE 600
QAVVLEQNLQ MLQTFISHRC DGNRNILHAC VSVCFPTSNK ETKEEEEAER SERNTFAERL 660
SAVEAIANAI SVVSSNGPGN RAGSSSSRSL RLREMMRRSL RAAGLGRHEA GASSSDHQDP 720
VSPPIAPPSW VPDPPSMDPD GDIDFILAPA VGSLTTAATG GGQGPSTSTI PGPSTEPSVV 780
ESKDRKANAH FILKLLCDSA VLQPYLRELL SAKDARGMTP FMSAVSGRAY PAAITILETA 840
QKIAKAEVSG SEKEEDVFMG MVCPSGTNPD DSPLYVLCCN DTCSFTWTGA EHINQDIFEC 900
RTCGLLESLC CCTECARVCH KGHDCKLKRT SPTAYCDCWE KCKCKTLIAG QKSARLDLLY 960
RLLTATNLVT LPNSRGEHLL LFLVQTVARQ TVEHCQYRPP RIREDRNRKT ASPDDSDMPD 1020
HDLEPPRFAQ LALERVLQDW NALRSMIMFG SQENKDPLSA SSRIGHLLPE EQVYLNQQSG 1080
TIRLDCFTHC LIVKCTADIL LLDTLLGTLV KELQNKYTPG RREEAIAVTM RFLRSVARVF 1140
VILSVEMASS KKKNNFIPQP IGKCKRVFQA LLPYAVEELC NVAESLIVPV RMGIARPTAP 1200
FTLASTSIDA MQGSEELFSV EPLPPRPSSD QSSSSSQSQS SYIIRNPQQR RISQSQPVRG 1260
REEEQDDIVS ADVEEVEVVE GVAGEEDHHD EQEEHGEENA EAEGHHDEHD EDGSDMELDL 1320
LAAAETESDS ESNHSNQDNA SGRRSVVTAA TAGSEAGASS VPAFFSEDDS QSNDSSDSDS 1380
SSSQSDDIEQ ETFMLDEPLE RTTNSSHANG AAQAPRSMQW AVRNTQHQRA ASTAPSSTST 1440
PAASSAGLIY IDPSNLRRSG TISTSAAAAA AALEASNASS YLTSASSLAR AYSIVIRQIS 1500
DLMGLIPKYN HLVYSQIPAA VKLTYQDAVN LQNYVEEKLI PTWNWMVSIM DSTEAQLRYG 1560
SALASAGDPG HPNHPLHASQ NSARRERMTA REEASLRTLE GRRRRATLLS ARQGMMSARG 1620
DFLNYALSLM RSHNDEHSDV LPVLDVCSLK HVAYVFQALI YWIKAMNQQT TLDTPQLERK 1680
RTRELLELGI DNEDSEHEND DDTSQSATLN DKDDESLPAE TGQNHPFFRR SDSMTFLGCI 1740
PPNPFEVPLA EAIPLADQPH LLQPNARKED LFGRPSQGLY SSSAGSGKCL VEVTMDRNCL 1800
EVLPTKMSYA ANLKNVMNMQ NRQKKAGEDQ SMLAEEADSS KPGPSAHDVA AQLKSSLLAE 1860
IGLTESEGPP LTSFRPQCSF MGMVISHDML LGRWRLSLEL FGRVFMEDVG AEPGSILTEL 1920
GGFEVKESKF RREMEKLRNQ QSRDLSLEVD RDRDLLIQQT MRQLNNHFGR RCATTPMAVH 1980
RVKVTFKDEP GEGSGVARSF YTAIAQAFLS NEKLPNLDCI QNANKGTHTS LMQRLRNRGE 2040
RDRERERERE MRRSSGLRAG SRRDRDRDFR RQLSIDTRPF RPASEGNPSD DPDPLPAHRQ 2100
ALGERLYPRV QAMQPAFASK ITGMLLELSP AQLLLLLASE DSLRARVEEA MELIVAHGRE 2160
NGADSILDLG LLDSSEKVQE NRKRHGSSRS VVDMDLDDTD DGDDNAPLFY QPGKRGFYTP 2220
RPGKNTEARL NCFRNIGRIL GLCLLQNELC PITLNRHVIK VLLGRKVNWH DFAFFDPVMY 2280
ESLRQLILAS QSSDADAVFS AMDLAFAVDL CKEEGGGQVE LIPNGVNIPV TPQNVYEYVR 2340
KYAEHRMLVV AEQPLHAMRK GLLDVLPKNS LEDLTAEDFR LLVNGCGEVN VQMLISFTSF 2400
NDESGENAEK LLQFKRWFWS IVERMSMTER QDLVYFWTSS PSLPASEEGF QPMPSITIRP 2460
PDDQHLPTAN TCISRLYVPL YSSKQILKQK LLLAIKTKNF GFV 2503 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0016567; P:protein ubiquitination; IEA:GOC. 
Interpro
 IPR000569; HECT.
 IPR002004; PABP_HYD.
 IPR009091; RCC1/BLIP-II.
 IPR003126; Znf_N-recognin.
 IPR013993; Znf_N-recognin_met. 
Pfam
 PF00632; HECT
 PF00658; PABP
 PF02207; zf-UBR 
SMART
 SM00119; HECTc
 SM00517; PolyA
 SM00396; ZnF_UBR1 
PROSITE
 PS50237; HECT
 PS51309; PABC
 PS51157; ZF_UBR 
PRINTS