CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008895
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 D-arabinono-1,4-lactone oxidase 
Protein Synonyms/Alias
 ALO; L-galactono-gamma-lactone oxidase 
Gene Name
 ALO1 
Gene Synonyms/Alias
 YML086C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
373SEPLDTSKRTNTSPGubiquitination[1]
498KKFRKIRKEQDPDNVubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Can oxidize L-gulono-1,4-lactone as well as D-arabinono- 1,4-lactone and L-galactono-1,4-lactone. 
Sequence Annotation
 DOMAIN 19 193 FAD-binding PCMH-type.
 MOD_RES 56 56 Pros-8alpha-FAD histidine (By  
Keyword
 Complete proteome; Direct protein sequencing; FAD; Flavoprotein; Membrane; Mitochondrion; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 526 AA 
Protein Sequence
MSTIPFRKNY VFKNWAGIYS AKPERYFQPS SIDEVVELVK SARLAEKSLV TVGSGHSPSN 60
MCVTDEWLVN LDRLDKVQKF VEYPELHYAD VTVDAGMRLY QLNEFLGAKG YSIQNLGSIS 120
EQSVAGIIST GSHGSSPYHG LISSQYVNLT IVNGKGELKF LDAENDPEVF KAALLSVGKI 180
GIIVSATIRV VPGFNIKSTQ EVITFENLLK QWDTLWTSSE FIRVWWYPYT RKCVLWRGNK 240
TTDAQNGPAK SWWGTKLGRF FYETLLWIST KIYAPLTPFV EKFVFNRQYG KLEKSSTGDV 300
NVTDSISGFN MDCLFSQFVD EWGCPMDNGL EVLRSLDHSI AQAAINKEFY VHVPMEVRCS 360
NTTLPSEPLD TSKRTNTSPG PVYGNVCRPF LDNTPSHCRF APLENVTNSQ LTLYINATIY 420
RPFGCNTPIH KWFTLFENTM MVAGGKPHWA KNFLGSTTLA AGPVKKDTDY DDFEMRGMAL 480
KVEEWYGEDL KKFRKIRKEQ DPDNVFLANK QWAIINGIID PSELSD 526 
Gene Ontology
 GO:0031307; C:integral to mitochondrial outer membrane; IDA:SGD.
 GO:0003885; F:D-arabinono-1,4-lactone oxidase activity; IDA:SGD.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0008762; F:UDP-N-acetylmuramate dehydrogenase activity; IEA:InterPro.
 GO:0034599; P:cellular response to oxidative stress; IMP:SGD.
 GO:0070485; P:dehydro-D-arabinono-1,4-lactone biosynthetic process; IMP:SGD. 
Interpro
 IPR007173; ALO.
 IPR016169; CO_DH_flavot_FAD-bd_sub2.
 IPR016166; FAD-bd_2.
 IPR016167; FAD-bd_2_sub1.
 IPR010031; FAD_lactone_oxidase.
 IPR023595; LGO_GLO.
 IPR006094; Oxid_FAD_bind_N.
 IPR006093; Oxy_OxRdtase_FAD_BS. 
Pfam
 PF04030; ALO
 PF01565; FAD_binding_4 
SMART
  
PROSITE
 PS51387; FAD_PCMH
 PS00862; OX2_COVAL_FAD 
PRINTS