CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023056
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Anaphase-promoting complex subunit 7 
Protein Synonyms/Alias
 APC7; Cyclosome subunit 7 
Gene Name
 ANAPC7 
Gene Synonyms/Alias
 APC7 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
99EYRNAVSKYTMALQQubiquitination[1]
288YFRAGDNKNSVLKFEubiquitination[1]
293DNKNSVLKFEQAQMLubiquitination[1]
364RALYLGAKAIQLNSNubiquitination[1]
379SVQALLLKGAALRNMubiquitination[1]
467KAKTLLDKALTQRPDubiquitination[1]
477TQRPDYIKAVVKKAEubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. 
Sequence Annotation
 REPEAT 77 110 TPR 1.
 REPEAT 169 202 TPR 2.
 REPEAT 271 304 TPR 3.
 REPEAT 373 406 TPR 4.
 REPEAT 441 475 TPR 5.
 REPEAT 476 508 TPR 6.
 REPEAT 509 542 TPR 7.  
Keyword
 3D-structure; Alternative splicing; Cell cycle; Cell division; Complete proteome; Mitosis; Reference proteome; Repeat; TPR repeat; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 599 AA 
Protein Sequence
MDPGDAAILE SSLRILYRLF ESVLPPLPAA LQSRMNVIDH VRDMAAAGLH SNVRLLSSLL 60
LTMSNNNPEL FSPPQKYQLL VYHADSLFHD KEYRNAVSKY TMALQQKKAL SKTSKVRPST 120
GNSASTPQSQ CLPSEIEVKY KMAECYTMLK QDKDAIAILD GIPSRQRTPK INMMLANLYK 180
KAGQERPSVT SYKEVLRQCP LALDAILGLL SLSVKGAEVA SMTMNVIQTV PNLDWLSVWI 240
KAYAFVHTGD NSRAISTICS LEKKSLLRDN VDLLGSLADL YFRAGDNKNS VLKFEQAQML 300
DPYLIKGMDV YGYLLAREGR LEDVENLGCR LFNISDQHAE PWVVSGCHSF YSKRYSRALY 360
LGAKAIQLNS NSVQALLLKG AALRNMGRVQ EAIIHFREAI RLAPCRLDCY EGLIECYLAS 420
NSIREAMVMA NNVYKTLGAN AQTLTLLATV CLEDPVTQEK AKTLLDKALT QRPDYIKAVV 480
KKAELLSREQ KYEDGIALLR NALANQSDCV LHRILGDFLV AVNEYQEAMD QYSIALR 537 
Gene Ontology
 GO:0005680; C:anaphase-promoting complex; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0007094; P:mitotic spindle assembly checkpoint; TAS:Reactome.
 GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.
 GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.
 GO:0070979; P:protein K11-linked ubiquitination; IDA:UniProtKB. 
Interpro
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2.
 IPR019734; TPR_repeat. 
Pfam
 PF07719; TPR_2 
SMART
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS