UniProt Accession

 TTC8_HUMAN; Q8TAM2; A6NFG2; B3KWA5; Q67B97; Q86SY0; Q86TV9; Q86U26; Q8NDH9; Q96DG8 

Genbank Protein ID

 AY366523; AY366524; BX161472; BX248071; BX248248; AY373972; AK124675; AL833901; AL121768; AL133238; CH471061; CH471061; BC001563; BC026351; BC095433 

Genbank Nucleotide ID

 AAR02192.1; AAR02193.1; CAD61928.1; CAD62360.1; CAD62576.1; AAR19043.1; BAG54067.1; CAD38757.2; EAW81400.1; EAW81402.1; AAH01563.1; AAH26351.1; AAH95433.1 

Protein Name

 Tetratricopeptide repeat protein 8 

Protein Synonyms/Alias

 TPR repeat protein 8; Bardet-Biedl syndrome 8 protein 

Gene Name

 TTC8 

Gene Synonyms/Alias

 BBS8 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
223	KQFKSALKQQEMVDT	ubiquitination	[1]
252	VTALNLFKQGLDKFP	ubiquitination	[1]
286	SSAAEYYKEVLKQDN	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. 

Sequence Annotation

 REPEAT 14 47 TPR 1.
 REPEAT 251 284 TPR 2.
 REPEAT 285 317 TPR 3.
 REPEAT 318 351 TPR 4.
 REPEAT 352 385 TPR 5.
 REPEAT 386 419 TPR 6.
 REPEAT 423 456 TPR 7.
 REPEAT 457 490 TPR 8.  

Keyword

 Alternative splicing; Bardet-Biedl syndrome; Cell membrane; Cell projection; Ciliopathy; Cilium; Cilium biogenesis/degradation; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Membrane; Mental retardation; Obesity; Reference proteome; Repeat; Retinitis pigmentosa; TPR repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 541 AA 

Protein Sequence

Gene Ontology

 GO:0034464; C:BBSome; IDA:BHF-UCL.
 GO:0005813; C:centrosome; IDA:BHF-UCL.
 GO:0005929; C:cilium; IDA:BHF-UCL.
 GO:0060170; C:cilium membrane; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005932; C:microtubule basal body; IDA:BHF-UCL.
 GO:0032391; C:photoreceptor connecting cilium; IEA:Compara.
 GO:0042384; P:cilium assembly; TAS:BHF-UCL.
 GO:0048560; P:establishment of anatomical structure orientation; IMP:BHF-UCL.
 GO:0045444; P:fat cell differentiation; IEA:Compara.
 GO:0050893; P:sensory processing; TAS:BHF-UCL. 

Interpro

 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2.
 IPR019734; TPR_repeat. 

Pfam

 PF00515; TPR_1
 PF07719; TPR_2
 PF13181; TPR_8 

SMART

 SM00028; TPR 

PROSITE

 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS