CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036441
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Transducin-like enhancer protein 3 
Protein Synonyms/Alias
  
Gene Name
 Tle3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
232KKRKAEEKDSLSRYDacetylation[1]
708KWFVSTGKDNLLNAWubiquitination[2]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 760 AA 
Protein Sequence
MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL ANEKTEMQRH 60
YVMYYEMSYG LNIEMHKQTE IAKRLNTILA QIMPFLSQEH QQQVAQAVER AKQVTMTELN 120
AIIGQQQLQA QHLSHATHGP PVQLPPHPSG LQPPGIPPVT GSSSGLLALG ALGSQAHLAV 180
KDEKNHHELD HRERESSTNN SVSPSESLRA SEKHRGSADY SMEAKKRKAE EKDSLSRYDS 240
DGDKSDDLVV DVSNEDPATP RVSPAHSPPE NGLDKARGLK KDAPTSPASV ASSSSTPSSK 300
TKDLGHNDKS STPGLKSNTP TPRNDAPTPG TSTTPGLRSM PASALRTPIT LTSSYPAPFA 360
MMSHHEMNGS LTSPSAYAGL HNIPSQMSAA AAAAAAAYGR SPMVSFGAVG FDPHPPMRAT 420
GLPSSLASIP GGKPAYSFHV SADGQMQPVP FPHDALAGPG IPRHARQINT LSHGEVVCAV 480
TISNPTRHVY TGGKGCVKIW DISQPGSKSP ISQLDCLNRD NYIRSCKLLP DGRTLIVGGE 540
ASTLTIWDLA SPTPRIKAEL TSSAPACYAL AISPDAKVCF SCCSDGNIAV WDLHNQTLVR 600
QFQGHTDGAS CIDISHDGTK LWTGGLDNTV RSWDLREGRQ LQQHDFTSQI FSLGYCPTGE 660
WLAVGMESSN VEVLHHTKPD KYQLHLHESC VLSLKFAYCG KWFVSTGKDN LLNAWRTPYG 720
ASIFQSKESS SVLSCDISAD DKYIVTGSGD KKATVYEVIY 760 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. 
Interpro
 IPR005617; Groucho/TLE_N.
 IPR009146; Groucho_enhance.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF03920; TLE_N
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR01850; GROUCHOFAMLY.