| Tag | Content |
|---|
| CPLM ID | CPLM-016536 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sialin |
Protein Synonyms/Alias | H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Solute carrier family 17 member 5; Vesicular H(+)/Aspartate-glutamate cotransporter |
Gene Name | Slc17a5 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 271 | EYIVSSLKNQLSSQK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential- dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva (By similarity). |
Sequence Annotation | MOTIF 22 23 Dileucine internalization motif (By
CARBOHYD 71 71 N-linked (GlcNAc...) (Potential).
CARBOHYD 77 77 N-linked (GlcNAc...) (Potential).
CARBOHYD 95 95 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Amino-acid transport; Cell junction; Cell membrane; Complete proteome; Cytoplasmic vesicle; Glycoprotein; Lysosome; Membrane; Reference proteome; Symport; Synapse; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 495 AA |
Protein Sequence | MRPLLRGPAG NDDEESSDST PLLPGARQTE AAPVCCSARY NLAILAFCGF FVLYALRVNL 60
SVALVDMVDS NTTLTDNRTS KECAEHSAPI KVHHNHTGKK YKWDAETQGW ILGSFFYGYI 120
VTQIPGGYIA SRVGGKLLLG LGILGTSVFT LFTPLAADLG VVTLVVLRAL EGLGEGVTFP 180
AMHAMWSSWA PPLERSKLLT ISYAGAQLGT VISLPLSGII CYYMNWTYVF YLFGIVGIVW 240
FILWMWIVSD TPETHKTISH YEKEYIVSSL KNQLSSQKVV PWGSILKSLP LWAIVVAHFS 300
YNWSFYTLLT LLPTYMKEIL RFNVQENGFL SALPYFGCWL CMILCGQAAD YLRVKWNFST 360
ISVRRIFSLV GMVGPAVFLV AAGFIGCDYS LAVAFLTIST TLGGFASSGF SINHLDIAPS 420
YAGILLGITN TFATIPGMTG PIIAKSLTPD NTIREWQTVF CIAAAINVFG AIFFTLFAKG 480
EVQSWALSDH HGHRN 495 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:MGI. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IDA:MGI. GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell. GO:0015136; F:sialic acid transmembrane transporter activity; IEA:Compara. GO:0015293; F:symporter activity; IEA:UniProtKB-KW. GO:0006865; P:amino acid transport; IEA:UniProtKB-KW. GO:0015739; P:sialic acid transport; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |