UniProt Accession

 CO9_MOUSE; P06683; Q91XA7 

Genbank Protein ID

 BC011137; X05475 

Genbank Nucleotide ID

 AAH11137.1; CAA29038.1 

Protein Name

 Complement component C9 

Protein Synonyms/Alias

  

Gene Name

 C9 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
368	DKASMKEKGVDLNDV	ubiquitination	[1]
443	REQAILLKEKILRGD	ubiquitination	[1]
493	KIKDAYIKKQNLEKA	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC. 

Sequence Annotation

 DOMAIN 40 93 TSP type-1.
 DOMAIN 97 134 LDL-receptor class A.
 DOMAIN 136 512 MACPF.
 DOMAIN 513 543 EGF-like.
 CARBOHYD 48 48 N-linked (GlcNAc...) (Potential).
 CARBOHYD 263 263 N-linked (GlcNAc...).
 CARBOHYD 417 417 N-linked (GlcNAc...) (Potential).
 DISULFID 41 76 By similarity.
 DISULFID 52 55 By similarity.
 DISULFID 86 92 By similarity.
 DISULFID 99 110 By similarity.
 DISULFID 105 123 By similarity.
 DISULFID 117 132 By similarity.
 DISULFID 140 179 By similarity.
 DISULFID 378 407 By similarity.
 DISULFID 513 529 By similarity.
 DISULFID 516 531 By similarity.
 DISULFID 533 542 By similarity.  

Keyword

 Cell membrane; Complement alternate pathway; Complement pathway; Complete proteome; Cytolysis; Disulfide bond; EGF-like domain; Glycoprotein; Immunity; Innate immunity; Membrane; Membrane attack complex; Reference proteome; Secreted; Signal; Transmembrane; Transmembrane beta strand. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 548 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0005579; C:membrane attack complex; IEA:UniProtKB-KW.
 GO:0006957; P:complement activation, alternative pathway; IEA:UniProtKB-KW.
 GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
 GO:0019835; P:cytolysis; IEA:UniProtKB-KW. 

Interpro

 IPR023415; LDLR_class-A_CS.
 IPR002172; LDrepeatLR_classA_rpt.
 IPR001862; MAC_perforin.
 IPR020864; MACPF.
 IPR020863; MACPF_CS.
 IPR000884; Thrombospondin_1_rpt. 

Pfam

 PF00057; Ldl_recept_a
 PF01823; MACPF 

SMART

 SM00192; LDLa
 SM00457; MACPF
 SM00209; TSP1 

PROSITE

 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS01209; LDLRA_1
 PS50068; LDLRA_2
 PS00279; MACPF_1
 PS51412; MACPF_2
 PS50092; TSP1 

PRINTS

 PR00764; COMPLEMENTC9.