UniProt Accession

 UCRI_MOUSE; Q9CR68; Q5SVV1 

Genbank Protein ID

 AK003966; AK012180; AK014470; AK153139; AK152391; AL611944; BC019934 

Genbank Nucleotide ID

 BAB23097.1; BAB28081.1; BAB29374.1; BAE31751.1; BAE31179.1; CAI24872.1; AAH19934.1 

Protein Name

 Cytochrome b-c1 complex subunit Rieske, mitochondrial 

Protein Synonyms/Alias

 Complex III subunit 5; Cytochrome b-c1 complex subunit 5; Rieske iron-sulfur protein; RISP; Ubiquinol-cytochrome c reductase iron-sulfur subunit; Cytochrome b-c1 complex subunit 11; Complex III subunit IX; Ubiquinol-cytochrome c reductase 8 kDa protein 

Gene Name

 Uqcrfs1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
46	EPPVLDVKRPFLCRE	acetylation	[1]
155	AMSKIEIKLSDIPEG	ubiquitination	[2]
163	LSDIPEGKNMAFKWR	acetylation	[3]
163	LSDIPEGKNMAFKWR	ubiquitination	[2]
168	EGKNMAFKWRGKPLF	acetylation	[1]
181	LFVRHRTKKEIDQEA	acetylation	[3]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. 

Sequence Annotation

 DOMAIN 187 272 Rieske.
 METAL 217 217 Iron-sulfur (2Fe-2S) (By similarity).
 METAL 219 219 Iron-sulfur (2Fe-2S); via pros nitrogen
 METAL 236 236 Iron-sulfur (2Fe-2S) (By similarity).
 METAL 239 239 Iron-sulfur (2Fe-2S); via pros nitrogen
 DISULFID 222 238 By similarity.  

Keyword

 2Fe-2S; Complete proteome; Direct protein sequencing; Disulfide bond; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Reference proteome; Respiratory chain; Transit peptide; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 274 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0005750; C:mitochondrial respiratory chain complex III; IEA:Compara.
 GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008121; F:ubiquinol-cytochrome-c reductase activity; IEA:EC.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
 GO:0046677; P:response to antibiotic; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0009725; P:response to hormone stimulus; IEA:Compara. 

Interpro

 IPR011070; Globular_prot_asu/bsu.
 IPR017941; Rieske_2Fe-2S.
 IPR014349; Rieske_Fe-S_prot.
 IPR005805; Rieske_Fe-S_prot_C.
 IPR015248; Ubiqinol_cyt_c_Rdtase_N.
 IPR006317; Ubiquinol_cyt_c_Rdtase_Fe-S-su.
 IPR004192; Ubiquinol_cyt_Rdtase_TM. 

Pfam

 PF00355; Rieske
 PF09165; Ubiq-Cytc-red_N
 PF02921; UCR_TM 

SMART

  

PROSITE

 PS51296; RIESKE 

PRINTS

 PR00162; RIESKE.