CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008374
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Matrix metalloproteinase-15 
Protein Synonyms/Alias
 MMP-15; Membrane-type matrix metalloproteinase 2; MT-MMP 2; MTMMP2; Membrane-type-2 matrix metalloproteinase; MT2-MMP; MT2MMP; SMCP-2 
Gene Name
 MMP15 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
662PRVLLYCKRSLQEWVubiquitination[1, 2]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A. 
Sequence Annotation
 REPEAT 367 415 Hemopexin 1.
 REPEAT 416 461 Hemopexin 2.
 REPEAT 463 511 Hemopexin 3.
 REPEAT 512 559 Hemopexin 4.
 MOTIF 109 116 Cysteine switch (By similarity).
 ACT_SITE 260 260 By similarity.
 METAL 111 111 Zinc; in inhibited form (By similarity).
 METAL 259 259 Zinc; catalytic (By similarity).
 METAL 263 263 Zinc; catalytic (By similarity).
 METAL 269 269 Zinc; catalytic (By similarity).
 MOD_RES 589 589 Phosphoserine.
 CARBOHYD 150 150 N-linked (GlcNAc...) (Potential).
 DISULFID 370 559 By similarity.  
Keyword
 Calcium; Cleavage on pair of basic residues; Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Membrane; Metal-binding; Metalloprotease; Phosphoprotein; Polymorphism; Protease; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix; Zinc; Zymogen. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 669 AA 
Protein Sequence
MGSDPSAPGR PGWTGSLLGD REEAARPRLL PLLLVLLGCL GLGVAAEDAE VHAENWLRLY 60
GYLPQPSRHM STMRSAQILA SALAEMQRFY GIPVTGVLDE ETKEWMKRPR CGVPDQFGVR 120
VKANLRRRRK RYALTGRKWN NHHLTFSIQN YTEKLGWYHS MEAVRRAFRV WEQATPLVFQ 180
EVPYEDIRLR RQKEADIMVL FASGFHGDSS PFDGTGGFLA HAYFPGPGLG GDTHFDADEP 240
WTFSSTDLHG NNLFLVAVHE LGHALGLEHS SNPNAIMAPF YQWKDVDNFK LPEDDLRGIQ 300
QLYGTPDGQP QPTQPLPTVT PRRPGRPDHR PPRPPQPPPP GGKPERPPKP GPPVQPRATE 360
RPDQYGPNIC DGDFDTVAML RGEMFVFKGR WFWRVRHNRV LDNYPMPIGH FWRGLPGDIS 420
AAYERQDGRF VFFKGDRYWL FREANLEPGY PQPLTSYGLG IPYDRIDTAI WWEPTGHTFF 480
FQEDRYWRFN EETQRGDPGY PKPISVWQGI PASPKGAFLS NDAAYTYFYK GTKYWKFDNE 540
RLRMEPGYPK SILRDFMGCQ EHVEPGPRWP DVARPPFNPH GGAEPGADSA EGDVGDGDGD 600
FGAGVNKDGG SRVVVQMEEV ARTVNVVMVL VPLLLLLCVL GLTYALVQMQ RKGAPRVLLY 660
CKRSLQEWV 669 
Gene Ontology
 GO:0031012; C:extracellular matrix; IEA:InterPro.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0008047; F:enzyme activator activity; TAS:ProtInc.
 GO:0004222; F:metalloendopeptidase activity; TAS:ProtInc.
 GO:0008270; F:zinc ion binding; TAS:ProtInc.
 GO:0006464; P:cellular protein modification process; TAS:ProtInc.
 GO:0030574; P:collagen catabolic process; TAS:Reactome.
 GO:0022617; P:extracellular matrix disassembly; TAS:Reactome.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0032355; P:response to estradiol stimulus; IEA:Compara. 
Interpro
 IPR000585; Hemopexin-like_dom.
 IPR018487; Hemopexin-like_repeat.
 IPR018486; Hemopexin_CS.
 IPR024079; MetalloPept_cat_dom.
 IPR001818; Pept_M10_metallopeptidase.
 IPR021190; Pept_M10A.
 IPR021805; Pept_M10A_metallopeptidase_C.
 IPR016293; Pept_M10A_Metazoans.
 IPR021158; Pept_M10A_Zn_BS.
 IPR006026; Peptidase_Metallo.
 IPR002477; Peptidoglycan-bd-like. 
Pfam
 PF11857; DUF3377
 PF00045; Hemopexin
 PF00413; Peptidase_M10
 PF01471; PG_binding_1 
SMART
 SM00120; HX
 SM00235; ZnMc 
PROSITE
 PS00546; CYSTEINE_SWITCH
 PS00024; HEMOPEXIN
 PS51642; HEMOPEXIN_2
 PS00142; ZINC_PROTEASE 
PRINTS
 PR00138; MATRIXIN.