| Tag | Content |
|---|
| CPLM ID | CPLM-016440 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D |
Protein Synonyms/Alias | N-acyl phosphatidylethanolamine phospholipase D; NAPE-PLD; NAPE-hydrolyzing phospholipase D |
Gene Name | Napepld |
Gene Synonyms/Alias | Mbldc1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 163 | PSQYMGPKRFRRPPC | ubiquitination | [1] | | 296 | PAFEEIGKRFGPFDL | ubiquitination | [1] | | 318 | YEPRWFMKYQHADPE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of anandamide (N- arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors. |
Sequence Annotation | METAL 185 185 Zinc 1 (Potential).
METAL 187 187 Zinc 1 (Potential).
METAL 189 189 Zinc 2 (Potential).
METAL 190 190 Zinc 2 (Potential).
METAL 253 253 Zinc 1 (Potential).
METAL 343 343 Zinc 2 (Potential). |
Keyword | Complete proteome; Hydrolase; Lipid degradation; Lipid metabolism; Membrane; Metal-binding; Phospholipid degradation; Phospholipid metabolism; Reference proteome; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 396 AA |
Protein Sequence | MDEYEDSQSP APSYQYPKET LRKRQNSVQN SGGSVSSRFS RKSFKLDYRL EEDVTKSKKG 60
KDGRFVNPWP TWKNISIPNV LRWLIMEKNH SGVPGSKEEL DKELPVLKPY FVSDPEDAGV 120
REAGLRVTWL GHATLMVEMD ELIFLTDPMF SSRASPSQYM GPKRFRRPPC TISELPTIDA 180
VLISHNHYDH LDYGSVLALN ERFGSELRWF VPLGLLDWMQ KCGCENVIEL DWWEENCVPG 240
HDKVTFVFTP SQHWCKRTLL DDNKVLWGSW SVLGPWSRFF FAGDTGYCPA FEEIGKRFGP 300
FDLAAIPIGA YEPRWFMKYQ HADPEDAVRI HIDLQTKRSV AIHWGTFALA NEHYLEPPVK 360
LNEALERYGL SCEDFFILKH GESRYLNTDD RAFEET 396 |
Gene Ontology | GO:0016020; C:membrane; IEA:UniProtKB-SubCell. GO:0070290; F:NAPE-specific phospholipase D activity; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0009395; P:phospholipid catabolic process; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |