CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014167
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 2-oxoglutarate dehydrogenase, mitochondrial 
Protein Synonyms/Alias
 2-oxoglutarate dehydrogenase complex component E1; OGDC-E1; Alpha-ketoglutarate dehydrogenase 
Gene Name
 Ogdh 
Gene Synonyms/Alias
 Ogdhl 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
237QCQWIRQKFETPGIMacetylation[1]
251MQFTNEEKRTLLARLacetylation[1]
401YCGDTEGKKVMSILLacetylation[1]
561EYEEEISKYDKICEEacetylation[1]
577FTRSKDEKILHIKHWacetylation[1]
697LHDQNVDKRTCIPMNacetylation[1]
860PLIVFTPKSLLRHPEacetylation[1]
897PAAQNPDKVKRLLFCacetylation[1]
899AQNPDKVKRLLFCTGacetylation[1]
943FPFDLLLKEAQKYPNacetylation[1]
970QGYYDYVKPRLRTTIacetylation[1]
1020AFDLDAFKKFS****acetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). 
Sequence Annotation
 MOD_RES 970 970 N6-acetyllysine (By similarity).
 CROSSLNK 534 534 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Acetylation; Complete proteome; Direct protein sequencing; Glycolysis; Isopeptide bond; Mitochondrion; Oxidoreductase; Reference proteome; Thiamine pyrophosphate; Transit peptide; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1023 AA 
Protein Sequence
MFHLRTCAAK LRPLTASQTV KTFSQNKPAA IRTFQQIRCY SAPVAAEPFL SGTSSNYVEE 60
MYCAWLENPK SVHKSWDIFF RNTNAGAPPG TAYQSPLSLS RSSLATMAHA QSLVEAQPNV 120
DKLVEDHLAV QSLIRAYQIR GHHVAQLDPL GILDADLDSS VPADIISSTD KLGFYGLHES 180
DLDKVFHLPT TTFIGGQEPA LPLREIIRRL EMAYCQHIGV EFMFINDLEQ CQWIRQKFET 240
PGIMQFTNEE KRTLLARLVR STRFEEFLQR KWSSEKRFGL EGCEVLIPAL KTIIDMSSAN 300
GVDYVIMGMP HRGRLNVLAN VIRKELEQIF CQFDSKLEAA DEGSGDMKYH LGMYHRRINR 360
VTDRNITLSL VANPSHLEAA DPVVMGKTKA EQFYCGDTEG KKVMSILLHG DAAFAGQGIV 420
YETFHLSDLP SYTTHGTVHV VVNNQIGFTT DPRMARSSPY PTDVARVVNA PIFHVNSDDP 480
EAVMYVCKVA AEWRNTFHKD VVVDLVCYRR NGHNEMDEPM FTQPLMYKQI RKQKPVLQKY 540
AELLVSQGVV NQPEYEEEIS KYDKICEEAF TRSKDEKILH IKHWLDSPWP GFFTLDGQPR 600
SMTCPSTGLE EDILTHIGNV ASSVPVENFT IHGGLSRILK TRRELVTNRT VDWALAEYMA 660
FGSLLKEGIH VRLSGQDVER GTFSHRHHVL HDQNVDKRTC IPMNHLWPNQ APYTVCNSSL 720
SEYGVLGFEL GFAMASPNAL VLWEAQFGDF NNMAQCIIDQ FICPGQAKWV RQNGIVLLLP 780
HGMEGMGPEH SSARPERFLQ MCNDDPDVLP NLQEENFDIS QLYDCNWIVV NCSTPGNFFH 840
VLRRQILLPF RKPLIVFTPK SLLRHPEART SFDEMLPGTH FQRVIPEDGP AAQNPDKVKR 900
LLFCTGKVYY DLTRERKARD MAEEVAITRI EQLSPFPFDL LLKEAQKYPN AELAWCQEEH 960
KNQGYYDYVK PRLRTTIDRA KPVWYAGRDP AAAPATGNKK THLTELQRFL DTAFDLDAFK 1020
KFS 1023 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0031966; C:mitochondrial membrane; ISS:UniProtKB.
 GO:0045252; C:oxoglutarate dehydrogenase complex; IDA:RGD.
 GO:0034602; F:oxoglutarate dehydrogenase (NAD+) activity; IEA:Compara.
 GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; ISS:UniProtKB.
 GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
 GO:0006103; P:2-oxoglutarate metabolic process; IDA:RGD.
 GO:0021695; P:cerebellar cortex development; IEA:Compara.
 GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
 GO:0021766; P:hippocampus development; IEA:Compara.
 GO:0006734; P:NADH metabolic process; IDA:RGD.
 GO:0061034; P:olfactory bulb mitral cell layer development; IEA:Compara.
 GO:0021860; P:pyramidal neuron development; IEA:Compara.
 GO:0021756; P:striatum development; IEA:Compara.
 GO:0006104; P:succinyl-CoA metabolic process; IDA:RGD.
 GO:0022028; P:tangential migration from the subventricular zone to the olfactory bulb; IEA:Compara.
 GO:0021794; P:thalamus development; IEA:Compara.
 GO:0006099; P:tricarboxylic acid cycle; IDA:RGD. 
Interpro
 IPR011603; 2oxoglutarate_DH_E1.
 IPR001017; DH_E1.
 IPR005475; Transketolase-like_Pyr-bd. 
Pfam
 PF00676; E1_dh
 PF02779; Transket_pyr 
SMART
 SM00861; Transket_pyr 
PROSITE
  
PRINTS