CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025661
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pyruvate kinase 
Protein Synonyms/Alias
  
Gene Name
 PKM2 
Gene Synonyms/Alias
 PKM 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
59DLPAVSEKDIQDLKFubiquitination[1]
101GEKGKNIKIISKIENubiquitination[1]
105KNIKIISKIENHEGVubiquitination[1]
146EKVFLAQKMMIGRCNubiquitination[1]
310GIFPVLCKDPVQEAWubiquitination[1]
333NFAMNVGKARGFFKKubiquitination[1]
Reference
 [1] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Glycolysis; Kinase; Magnesium; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 366 AA 
Protein Sequence
MSKPHSEAGT AFIQTQQLHA AMADTFLEHM CRLDIDSPPS KKGVNLPGAA VDLPAVSEKD 60
IQDLKFGVEQ DVDMVFASFI RKASDVHEVR KVLGEKGKNI KIISKIENHE GVRRFDEILE 120
ASDGIMVARG DLGIEIPAEK VFLAQKMMIG RCNRAGKPVI CATQMLESMI KKPRPTRAEG 180
SDVANAVLDG ADCIMLSGET AKGDYPLEAV RMQHLIAREA EAAMFHRKLF EELVRASSHS 240
TDLMEAMAMG SVEASYKCLA AALIVLTESG RSAHQVARYR PRAPIIAVTR NPQTARQAHL 300
YRGIFPVLCK DPVQEAWAED VDLRVNFAMN VGKARGFFKK GDVVIVLTGW RPGSGFTNTM 360
RVVPVP 366 
Gene Ontology
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0030955; F:potassium ion binding; IEA:InterPro.
 GO:0004743; F:pyruvate kinase activity; IEA:EC.
 GO:0006096; P:glycolysis; IEA:UniProtKB-UniPathway. 
Interpro
 IPR001697; Pyr_Knase.
 IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
 IPR015794; Pyrv_Knase_a/b.
 IPR018209; Pyrv_Knase_AS.
 IPR015793; Pyrv_Knase_brl.
 IPR015795; Pyrv_Knase_C. 
Pfam
 PF00224; PK
 PF02887; PK_C 
SMART
  
PROSITE
 PS00110; PYRUVATE_KINASE 
PRINTS
 PR01050; PYRUVTKNASE.