UniProt Accession

 NPTX1_HUMAN; Q15818; B3KXH3; Q5FWE6 

Genbank Protein ID

 U61849; AK127335; BC089441 

Genbank Nucleotide ID

 AAC50727.1; BAG54485.1; AAH89441.1 

Protein Name

 Neuronal pentraxin-1 

Protein Synonyms/Alias

 NP1; Neuronal pentraxin I; NP-I 

Gene Name

 NPTX1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
141	GQTLQSLKTRLENLE	ubiquitination	[1]
169	LKDLLQSKIDELERQ	ubiquitination	[2]
200	NDTEERVKIETALTS	ubiquitination	[1]
385	HFNIWDRKLTPGEVY	ubiquitination	[1]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses (By similarity). 

Sequence Annotation

 DOMAIN 230 432 Pentaxin.
 METAL 280 280 Calcium 1 (By similarity).
 METAL 358 358 Calcium 1 (By similarity).
 METAL 358 358 Calcium 2 (By similarity).
 METAL 359 359 Calcium 1; via carbonyl oxygen (By
 METAL 360 360 Calcium 1 (By similarity).
 METAL 360 360 Calcium 2 (By similarity).
 METAL 370 370 Calcium 2 (By similarity).
 CARBOHYD 154 154 N-linked (GlcNAc...) (Potential).
 CARBOHYD 193 193 N-linked (GlcNAc...) (Potential).
 DISULFID 256 316 By similarity.  

Keyword

 Calcium; Complete proteome; Cytoplasmic vesicle; Disulfide bond; Glycoprotein; Metal-binding; Reference proteome; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 432 AA 

Protein Sequence

Gene Ontology

 GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0060385; P:axonogenesis involved in innervation; IEA:Compara.
 GO:0007417; P:central nervous system development; TAS:ProtInc.
 GO:0007268; P:synaptic transmission; TAS:ProtInc.
 GO:0006810; P:transport; TAS:ProtInc. 

Interpro

 IPR008985; ConA-like_lec_gl_sf.
 IPR013320; ConA-like_subgrp.
 IPR001759; Pentaxin. 

Pfam

 PF00354; Pentaxin 

SMART

 SM00159; PTX 

PROSITE

 PS00289; PENTAXIN 

PRINTS

 PR00895; PENTAXIN.