| Tag | Content |
|---|
| CPLM ID | CPLM-021148 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Junctophilin-3 |
Protein Synonyms/Alias | JP-3; Junctophilin type 3 |
Gene Name | Jph3 |
Gene Synonyms/Alias | Jp3 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 84 | SKGKWVYKGEWTHGF | ubiquitination | [1] | | 92 | GEWTHGFKGRYGVRE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory. |
Sequence Annotation | REPEAT 15 37 MORN 1.
REPEAT 39 60 MORN 2.
REPEAT 61 82 MORN 3.
REPEAT 83 105 MORN 4.
REPEAT 107 129 MORN 5.
REPEAT 130 152 MORN 6.
REPEAT 288 310 MORN 7.
REPEAT 311 333 MORN 8.
MOD_RES 420 420 Phosphoserine.
MOD_RES 506 506 Phosphoserine. |
Keyword | Cell membrane; Complete proteome; Endoplasmic reticulum; Membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 744 AA |
Protein Sequence | MSSGGRFNFD DGGSYCGGWE DGKAHGHGVC TGPKGQGEYT GSWSHGFEVL GVYTWPSGNT 60
YQGTWAQGKR HGIGLESKGK WVYKGEWTHG FKGRYGVREC TGNGAKYEGT WSNGLQDGYG 120
TETYSDGGTY QGQWVGGMRQ GYGVRQSVPY GMAAVIRSPL RTSINSLRSE HTNGAALHPD 180
ASPAVAGSPA VSRGGFVLVA HSDSEILKSK KKGLFRRSLL SGLKLRKSES KSSLASQRSK 240
QSSFRSEAGM STVSSTASDI HSTISLGEAE AELAVIEDDI DATTTETYVG EWKNDKRSGF 300
GVSQRSDGLK YEGEWVSNRR HGYGCMTFPD GTKEEGKYKQ NVLVSGKRKN LIPLRASKIR 360
EKVDRAVEAA ERAATIAKQK AEIAASRTSH SRAKAEAALT AAQKAQEEAR IARITAKEFS 420
PSFQHRENGL EYQRPKHQMS CDDIEVLSTG TPLQQESPEL YRKGTTPSDL TPDDSPLQSF 480
PASPTSTPPP APASRTKMAH FSRQVSVDEE RSGDIQMLLE GRGGDYARNS WGEEKAGASR 540
GIRSGALRSG QPTEDFRTRG SGHKQPGNPK PRERRTESPT TFSWTSHHRA GNPCSGGPKL 600
LEPDEEQLSN YKLEMKPLLR MDACPQDTHP QRRRHSRGAG GDRGFGLQRL RSKSQNKENL 660
RPASSAEPTV QKLESLRLGD RPEPRLLRWD LTFSPPQKSL PVALESDEET GDELKSSTGS 720
APILVVMVIL LNIGVAILFI NFFI 744 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB. GO:0016021; C:integral to membrane; TAS:MGI. GO:0030314; C:junctional membrane complex; IDA:UniProtKB. GO:0005886; C:plasma membrane; IDA:UniProtKB. GO:0015278; F:calcium-release channel activity; IMP:UniProtKB. GO:0035640; P:exploration behavior; IMP:UniProtKB. GO:0007612; P:learning; IGI:MGI. GO:0040011; P:locomotion; IMP:MGI. GO:0007613; P:memory; IMP:UniProtKB. GO:0050885; P:neuromuscular process controlling balance; IGI:MGI. GO:0048168; P:regulation of neuronal synaptic plasticity; IMP:UniProtKB. GO:0060314; P:regulation of ryanodine-sensitive calcium-release channel activity; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |