CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024565
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Zinc finger protein 891 
Protein Synonyms/Alias
  
Gene Name
 ZNF891 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
374VRTHTGEKPYECNQCubiquitination[1]
486IRTHTGEKPYECKECubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 May be involved in transcriptional regulation (By similarity). 
Sequence Annotation
 DOMAIN 43 113 KRAB.
 ZN_FING 320 342 C2H2-type 1; degenerate.
 ZN_FING 348 370 C2H2-type 2.
 ZN_FING 376 398 C2H2-type 3.
 ZN_FING 404 426 C2H2-type 4.
 ZN_FING 432 454 C2H2-type 5.
 ZN_FING 460 482 C2H2-type 6.
 ZN_FING 488 510 C2H2-type 7.
 ZN_FING 516 538 C2H2-type 8.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 544 AA 
Protein Sequence
MAVMDLSSPW ALTKQDSACF HLRNAEEERM IAVFLTTWLQ EPMTFKDVAV EFTQEEWMML 60
DSAQRSLYRD VMLENYRNLT SVEYQLYRLT VISPLDQEEI RNMKKRIPQA ICPDQKIQPK 120
TKESTVQKIL WEEPSNAVKM IKLTMHNWSS TLREDWECHK IRKQHKIPGG HWRQMIYAPK 180
KTVPQELFRD YHELEENSKL GSKLIFSQSI FTSKHCQKCY SEIGCLKHNS IINNYVKNSI 240
SEKLYESHEC DTTLWHFQRN QTVQKEYTYS KHGMHFTHNM FPVPNNLHMA QNACECNKDE 300
TLCHQSSLKK QGQTHTEKKH ECNQCGKAFK RISNLTLYKK SHMGEKQYEC KECGKVFNDS 360
STLRRHVRTH TGEKPYECNQ CGKAFSQKTS LKAHMRTHTG EKPYECNQCG KSFGTSSYLI 420
VHKRIHTGEK LYECSECGKA FNTSSHLKVH KKIHTGENVY ECSDCGKVFS GVSSLRMHIR 480
THTGEKPYEC KECRKAFSVS SSLRRHVRIH TGEKPYECIQ CGKAFSQSSS LIIHKRIHTE 540
RETL 544 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS