CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031974
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Exocyst complex component 4 
Protein Synonyms/Alias
 cDNA FLJ53330, highly similar to Exocyst complex component 4 
Gene Name
 EXOC4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
12CKRDELRKLWIEGIEubiquitination[1]
39NIKQVPQKLEQCMASubiquitination[1, 2]
116QRNKEKGKISSLVKDubiquitination[1]
122GKISSLVKDASVPLIubiquitination[1, 2, 3]
139TNLPTPRKFLDTSHYubiquitination[1, 2, 3]
331FAAFFAKKKPQRPKNubiquitination[1]
385LIEGGGTKFVCKPGAubiquitination[1]
389GGTKFVCKPGARNITubiquitination[1]
561WMNMAQPKQLRPKREubiquitination[1]
852NTRLQRLKEIICEQAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 873 AA 
Protein Sequence
MLLHCKRDEL RKLWIEGIEH KHVLNLLDEI ENIKQVPQKL EQCMASKHYL SATDMLVSAV 60
ESLEGPLLQV EGLSDLRLEL HSKKMNLHLV LIDELHRHLY IKSTSRVVQR NKEKGKISSL 120
VKDASVPLID VTNLPTPRKF LDTSHYSTAG SSSVREINLQ DIKEDLELDP EENSTLFMGI 180
LIKGLAKLKK IPETVKAIIE RLEQELKQIV KRSTTQVADS GYQRGENVTV ENQPRLLLEL 240
LELLFDKFNA VAAAHSVVLG YLQDTVVTPL TQQEDIKLYD MADVWVKIQD VLQMLLTEYL 300
DMKNTRTASE PSAQLSYAST GREFAAFFAK KKPQRPKNSL FKFESSSHAI SMSAYLREQR 360
RELYSRSGEL QGGPDDNLIE GGGTKFVCKP GARNITVIFH PLLRFIQEIE HALGLGPAKQ 420
CPLREFLTVY IKNIFLNQVL AEINKEIEGV TKTSDPLKIL ANADTMKVLG VQRPLLQSTI 480
IVEKTVQDLL NLMHDLSAYS DQFLNMVCVK LQEYKDTCTA AYRGIVQSEE KLVISASWAK 540
DDDISRLLKS LPNWMNMAQP KQLRPKREEE EDFIRAAFGK ESEVLIGNLG DKLIPPQDIL 600
RDVSDLKALA NMHESLEWLA SRTKSAFSNL STSQMLSPAQ DSHTNTDLPP VSEQIMQTLS 660
ELAKSFQDMA DRCLLVLHLE VRVHCFHYLI PLAKEGNYAI VANVESMDYD PLVVKLNKDI 720
SAIEEAMSAS LQQHKFQYIF EGLGHLISCI LINGAQYFRR ISESGIKKMC RNIFVLQQNL 780
TNITMSREAD LDFARQYYEM LYNTADELLN LVVDQGVKYT ELEYIHALTL LHRSQTGVGE 840
LTTQNTRLQR LKEIICEQAA IKQATKDKKI TTV 873 
Gene Ontology
 GO:0000145; C:exocyst; IEA:InterPro.
 GO:0032584; C:growth cone membrane; IEA:Compara.
 GO:0035748; C:myelin sheath abaxonal region; IEA:Compara.
 GO:0015031; P:protein transport; IEA:InterPro.
 GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro. 
Interpro
 IPR007191; Sec8_exocyst. 
Pfam
 PF04048; Sec8_exocyst 
SMART
  
PROSITE
  
PRINTS