CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032321
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Wapal protein 
Protein Synonyms/Alias
 Wings apart-like protein homolog 
Gene Name
 Wapal 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
52GQKRPNFKPDIQEIPacetylation[1]
168TKLLTSDKVENFSEEacetylation[1, 2]
321QGASNFDKLMDGTSQacetylation[3]
321QGASNFDKLMDGTSQubiquitination[4]
627QEIVTALKCRKEDKEubiquitination[4]
761EQDASSAKLLNEKDMubiquitination[4]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1194 AA 
Protein Sequence
MTSRFGKTYS RKGGNGSSKF DEVFSNKRTT LSTKWGETTF MAKLGQKRPN FKPDIQEIPK 60
KPKVEEEDTG DPFGFDSDDE SLPVSSKNLA QGKGSSYSES SEAAQLEEVT SVFEANSKCS 120
HVVGEDSFAS DRCLLVEDTL IGKEKSISRI PEDNANKSSC TKLLTSDKVE NFSEEHEKNS 180
HHFHKNAEDS TKKPNAETAV ASEYKADETK ETNDTWNSQS GKRTESPSES CPVKGSVRTG 240
LYEWDNDFED IRSEDCILSL DNESLLEMKD EDLKNRIGGL ENLNETFEED IIQSVLRPSN 300
CRTYCRANKA RSSQGASNFD KLMDGTSQSL AKANSESSKD GLNQAKKGSA SCGTSFRGTV 360
GRTRDYTVLH PSCLSVCNVT IQDTMERSMD EFTASTPADL GEAGRLRKKA DIATSKTTTR 420
FRPSNTKSKK DVKLEFFGFE DHDETGGDEG GSGSSNYKIK YFGFDDLSES EDDDDDDCQV 480
ERKKDKKRTK TAPSPSQQPP PESSDNSQDS QSSTNNAEDL PGVPESVKKP ISKQGDKSKE 540
NTRKIFSGPK RSPTKAVYNA RHWNHPDSEE LPGPPIAKPQ RVTVRLSSKE PNQKDDGVFK 600
APAPPLKVIK TVTIPTQPYQ EIVTALKCRK EDKELYTVVQ HVKHFNDVVE FGENQEFTDD 660
IEYLLSGLKS TQPLNTRCLS VISLATKCAM PSFRMHLRAH GMVAMVFKTL DDSQHHQNLS 720
LCTAALMYIL SRDRLNMDLD RASLDLMIRL LELEQDASSA KLLNEKDMNK IKEKIRRLCE 780
TVHNKHLDLE NITTGHLAME TLLSLTSKRA GDWFKEELRL LGGLDHIVDK VKECVDHLSR 840
DDEDEEKLVA SLWGAERCLR VLESVTVHNP ENQSYLIAYK DSQLIISSAK ALQHCEDLIQ 900
QYNRAENSIC VADSNPLPYQ NVTNHVGKAV EDCMRAIIGV LLNLTNDNEW GSTKTGEQEG 960
LIGTAMNCVL QVPKYLPQEQ RFDIRVLGLG LLINLVEYSA RNRHCLVNMQ TSCSFDSSFS 1020
SGEGDHSLRL AGQVHAVQAL VQLFLERERA AQLAESKTDE LIKDAPTTQH DKSGEWQETS 1080
GEIQWVSTEK TDGAEEKQKK EEEDEELDLN KALQHAGKHM EDCIVASYTA LLLGCLCQES 1140
PINVTTVREY LPEGDFSIMT EMLKKFLSFM NLTCAVGTTG QKSISRVIEY LEHC 1194 
Gene Ontology
 GO:0000795; C:synaptonemal complex; IDA:MGI.
 GO:0009636; P:response to toxic substance; IDA:MGI. 
Interpro
 IPR016024; ARM-type_fold.
 IPR012502; WAPL_metazoan_plants.
 IPR022771; WAPL_prot. 
Pfam
 PF07814; WAPL 
SMART
  
PROSITE
 PS51271; WAPL 
PRINTS