UniProt Accession

 WRB_HUMAN; O00258; A8KAP8; A8MQ44; D3DSH9; O60740 

Genbank Protein ID

 Y12478; AK293113; AK299144; AF064861; AF121781; AL163279; CH471079; CH471079; CH471079; BC012415 

Genbank Nucleotide ID

 CAA73081.1; BAF85802.1; BAG61196.1; CAB90454.1; EAX09645.1; EAX09647.1; EAX09649.1; AAH12415.1 

Protein Name

 Tail-anchored protein insertion receptor WRB 

Protein Synonyms/Alias

 Congenital heart disease 5 protein; Tryptophan-rich basic protein; WRB 

Gene Name

 WRB 

Gene Synonyms/Alias

 CHD5 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
41	FMSRVLQKDAEQESQ	ubiquitination	[1, 2, 3]
57	RAEIQDMKQELSTVN	ubiquitination	[1, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Receptor for ASNA1/TRC40-mediated insertion of tail- anchored (TA) proteins into the ER membrane. 

Sequence Annotation

 REGION 39 97 Interaction with ASNA1/TRC40.  

Keyword

 Alternative splicing; Coiled coil; Complete proteome; Endoplasmic reticulum; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 174 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005730; C:nucleolus; IDA:HPA. 

Interpro

  

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SMART

  

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PRINTS