| Tag | Content |
|---|
| CPLM ID | CPLM-022407 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | RB-associated KRAB zinc finger protein |
Protein Synonyms/Alias | RB-associated KRAB repressor; hRBaK; Zinc finger protein 769 |
Gene Name | RBAK |
Gene Synonyms/Alias | ZNF769 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 537 | QPLPKGEKSYECNVC | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | May repress E2F-dependent transcription. May promote AR- dependent transcription. |
Sequence Annotation | DOMAIN 8 79 KRAB.
ZN_FING 261 283 C2H2-type 1.
ZN_FING 289 311 C2H2-type 2.
ZN_FING 317 339 C2H2-type 3.
ZN_FING 345 367 C2H2-type 4.
ZN_FING 373 395 C2H2-type 5.
ZN_FING 401 423 C2H2-type 6.
ZN_FING 429 451 C2H2-type 7.
ZN_FING 457 479 C2H2-type 8.
ZN_FING 485 505 C2H2-type 9.
ZN_FING 511 533 C2H2-type 10; degenerate.
ZN_FING 539 561 C2H2-type 11.
ZN_FING 567 589 C2H2-type 12.
ZN_FING 595 617 C2H2-type 13.
ZN_FING 623 645 C2H2-type 14.
ZN_FING 651 673 C2H2-type 15.
ZN_FING 679 701 C2H2-type 16.
REGION 171 260 Required for interaction with RB1.
REGION 417 714 Interaction with AR. |
Keyword | Activator; Alternative splicing; Complete proteome; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 714 AA |
Protein Sequence | MNTLQGPVSF KDVAVDFTQE EWQQLDPDEK ITYRDVMLEN YSHLVSVGYD TTKPNVIIKL 60
EQGEEPWIMG GEFPCQHSPE AWRVDDLIER IQENEDKHSR QAACINSKTL TEEKENTFSQ 120
IYMETSLVPS SIIAHNCVSC GKNLESISQL ISSDGSYART KPDECNECGK TYHGEKMCEF 180
NQNGDTYSHN EENILQKISI LEKPFEYNEC MEALDNEAVF IAHKRAYIGE KPYEWNDSGP 240
DFIQMSNFNA YQRSQMEMKP FECSECGKSF CKKSKFIIHQ RAHTGEKPYE CNVCGKSFSQ 300
KGTLTVHRRS HLEEKPYKCN ECGKTFCQKL HLTQHLRTHS GEKPYECSEC GKTFCQKTHL 360
TLHQRNHSGE RPYPCNECGK SFSRKSALSD HQRTHTGEKL YKCNECGKSY YRKSTLITHQ 420
RTHTGEKPYQ CSECGKFFSR VSYLTIHYRS HLEEKPYECN ECGKTFNLNS AFIRHRKVHT 480
EEKSHECSEC GKFSQLYLTD HHTAHLEEKP YECNECGKTF LVNSAFDGHQ PLPKGEKSYE 540
CNVCGKLFNE LSYYTEHYRS HSEEKPYGCS ECGKTFSHNS SLFRHQRVHT GEKPYECYEC 600
GKFFSQKSYL TIHHRIHSGE KPYECSKCGK VFSRMSNLTV HYRSHSGEKP YECNECGKVF 660
SQKSYLTVHY RTHSGEKPYE CNECGKKFHH RSAFNSHQRI HRRGNMNVLD VENL 714 |
Gene Ontology | GO:0005634; C:nucleus; TAS:UniProtKB. GO:0003676; F:nucleic acid binding; IEA:InterPro. GO:0008270; F:zinc ion binding; NAS:UniProtKB. GO:0045892; P:negative regulation of transcription, DNA-dependent; TAS:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |