UniProt Accession

 PMM_YEAST; P07283; D6VTI5; Q70D76; Q70D77 

Genbank Protein ID

 X03213; AJ585720; AJ585721; AJ585722; AJ585723; AJ585724; AJ585725; AJ585726; AJ585727; AJ585728; AJ585729; AJ585730; AJ585731; AJ585732; AJ585733; AJ585734; AJ585735; D50617; AY692959; BK006940 

Genbank Nucleotide ID

 CAA26957.1; CAE52240.1; CAE52241.1; CAE52242.1; CAE52243.1; CAE52244.1; CAE52245.1; CAE52246.1; CAE52247.1; CAE52248.1; CAE52249.1; CAE52250.1; CAE52251.1; CAE52252.1; CAE52253.1; CAE52254.1; CAE52255.1; BAA09196.1; AAT92978.1; DAA12395.1 

Protein Name

 Phosphomannomutase 

Protein Synonyms/Alias

 PMM 

Gene Name

 SEC53 

Gene Synonyms/Alias

 ALG4; YFL045C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
45	TLAKLRNKCCIGFVG	ubiquitination	[1]
163	KEHQIRAKFVEALKK	acetylation	[2]
205	YCLQHVEKDGFKEIH	acetylation	[2]
209	HVEKDGFKEIHFFGD	acetylation	[2]
246	QSPDDTVKILTELFN	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. 

Sequence Annotation

 ACT_SITE 19 19 Nucleophile (By similarity).
 ACT_SITE 21 21 By similarity.
 ACT_SITE 54 54 By similarity.
 ACT_SITE 196 196 By similarity.
 BINDING 28 28 Substrate (By similarity).
 BINDING 130 130 Substrate (By similarity).
 BINDING 141 141 Substrate (By similarity).
 BINDING 148 148 Substrate (By similarity).
 BINDING 186 186 Substrate (By similarity).
 BINDING 188 188 Substrate (By similarity).
 MOD_RES 240 240 Phosphoserine.  

Keyword

 Complete proteome; Cytoplasm; Isomerase; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 254 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0004615; F:phosphomannomutase activity; IDA:SGD.
 GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0019307; P:mannose biosynthetic process; IEA:InterPro.
 GO:0045047; P:protein targeting to ER; IMP:SGD. 

Interpro

 IPR023214; HAD-like_dom.
 IPR006379; HAD-SF_hydro_IIB.
 IPR005002; PMM. 

Pfam

 PF03332; PMM 

SMART

  

PROSITE

  

PRINTS