| Tag | Content |
|---|
| CPLM ID | CPLM-011846 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Probable 2-methylcitrate dehydratase |
Protein Synonyms/Alias | |
Gene Name | PDH1 |
Gene Synonyms/Alias | YPR002W; LPZ2W; YP9723.02 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 46 | KVLKDIAKYVHETPL | acetylation | [1] | | 488 | HFVESPDKVDLIMKV | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Catalyzes the dehydration of 2-methylcitrate to 2- methyl-cis-aconitate (By similarity). |
Sequence Annotation | |
Keyword | 2Fe-2S; Complete proteome; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 516 AA |
Protein Sequence | MFLAKNLKNN KIKVCLPKKK FAALSTASIQ TNERPNPDKV LKDIAKYVHE TPLKSSLALD 60
TARLCFLDTL GCGLAALKFK QAQNIIKPIV PGTIVPSGTK ILGTSYVMDP VKGAFAIGTL 120
IRWLDYNDCW LAAEWGHPSD NLGGILAVAD HLSRLNKATH GKNGKQFLVK DVLEAMIKAH 180
EIQGIIALEN SFNKVGLDHV VLVKVATAGV VSKMLGLSQE QTIEALSQAF VDGQSLRTYR 240
HAPNTGSRKS WAAGDAVSRA VNLAYLVKNA NVGTIPSVLT ARTWGFYDVL FKGKPFSFQQ 300
RSKYDSYVME NVLFKISFPA EFHAQTAVEA AVKAYRILAK QGKTFKDIKS IRIRTQEAAM 360
RIIDKSGPLY NYADRDHCIQ YMIAVPLITG NLTATDYSDE VARNPEIDNL RSKMYCIEDT 420
HLTQNYHDPD KRSIGNALLI ELNDGTQLDE IFVEYPVGHK FRREEGIPLL MNKFQRHLRE 480
HFVESPDKVD LIMKVSSKTN FLNMQIDKYM DLFTEG 516 |
Gene Ontology | GO:0005741; C:mitochondrial outer membrane; IDA:SGD. GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW. GO:0047547; F:2-methylcitrate dehydratase activity; ISA:SGD. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0019629; P:propionate catabolic process, 2-methylcitrate cycle; ISA:SGD. |
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